BRENDA - Enzyme Database show
show all sequences of 2.8.3.13

Substrate specificity of a dicarboxyl-CoA: dicarboxylic acid coenzyme A transferase from rat liver mitochondria

Deana, R.; Biochem. Int. 26, 767-773 (1992)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.07
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
0.07
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
0.11
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.13
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
0.15
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
0.16
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.18
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate, reverse reaction
Rattus norvegicus
0.18
-
Glutarate
pH 7.8, 30°C, cosubstrate adipylCoA
Rattus norvegicus
0.18
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.26
-
Glutarate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
0.26
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
0.27
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.28
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.33
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
0.38
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.39
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate or glutarate, reverse reaction
Rattus norvegicus
0.39
-
adipate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
0.4
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.45
-
Glutarate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
0.45
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.5
-
Glutarate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA
Rattus norvegicus
0.5
-
succinate
pH 7.8, 30°C, cosubstrate glutarylCoA
Rattus norvegicus
0.52
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.55
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.62
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate, reverse reaction
Rattus norvegicus
0.65
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.68
-
succinate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
0.7
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.72
-
adipate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
0.72
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate or adipate
Rattus norvegicus
0.73
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.74
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.75
-
succinylCoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.76
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
0.83
-
adipate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
0.83
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.84
-
Glutarate
pH 7.8, 30°C, cosubstrate methylmalonylCoA
Rattus norvegicus
0.87
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.88
-
succinate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
0.95
-
succinate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
1.01
-
malonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
1.2
-
succinate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
1.25
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
1.32
-
adipate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
1.42
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
1.51
-
adipate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
1.55
-
malonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
1.63
-
malonate
pH 7.8, 30°C, cosubstrate succinyl-CoA or methylmalonyl-CoA
Rattus norvegicus
1.71
-
malonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
1.8
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate malonyl-CoA
Rattus norvegicus
1.95
-
methylmalonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
2.2
-
methylmalonate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.33
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.44
-
methylmalonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.7
-
methylmalonate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
3.05
-
methylmalonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinyl-CoA + 3-hydroxy-3-methylglutarate
Rattus norvegicus
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
Rattus norvegicus
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxy-3-methylglutaryl-CoA + adipate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + glutarate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + glutaryl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + malonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + succinate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + 3-hydroxy-3-methylglutarate
adipyl-CoA shows highest apparent affinty, forward reaction at 64%, reverse reaction at 32% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + glutarate
forward reaction at 82%, reverse reaction at 68% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + glutaryl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + malonate
forward reaction at 40%, reverse reaction at 43% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + malonyl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + methylmalonate
poor substrate, succinyl-CoA, glutaryl-CoA, malonyl-CoA or 3-hydroxy-3-methylglutaryl-CoA can replace adipyl-CoA
643834
Rattus norvegicus
adipate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + succinate
best substrates, reverse reaction at 38% the rate of forward reaction
643834
Rattus norvegicus
adipate + succinyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + 3-hydroxy-3-methylglutarate
forward and reverse reaction at 50% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + adipate
-
643834
Rattus norvegicus
glutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + malonate
forward reaction at 33%, reverse reaction at 41% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
glutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + succinate
-
643834
Rattus norvegicus
glutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + 3-hydroxy-3-methylglutarate
forward reaction at 34%, reverse reaction at 23% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
malonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + adipate
-
643834
Rattus norvegicus
malonate + adipyl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + glutarate
-
643834
Rattus norvegicus
malonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + methylmalonate
-
643834
Rattus norvegicus
malonate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + succinate
-
643834
Rattus norvegicus
malonate + succinyl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
methylmalonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + adipate
-
643834
Rattus norvegicus
methylmalonate + adipyl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + glutarate
-
643834
Rattus norvegicus
methylmalonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + malonate
-
643834
Rattus norvegicus
methylmalonate + malonyl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + succinate
-
643834
Rattus norvegicus
methylmalonate + succinyl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + adipate
-
643834
Rattus norvegicus
succinate + adipyl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + glutarate
forward reaction at 58%, reverse reaction at 55% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + glutaryl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + malonate
forward reaction at 29%, reverse reaction at 22% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + malonyl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + methylmalonate
-
643834
Rattus norvegicus
succinate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.07
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
0.07
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
0.11
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.13
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
0.15
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate glutarate
Rattus norvegicus
0.16
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.18
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate adipate, reverse reaction
Rattus norvegicus
0.18
-
Glutarate
pH 7.8, 30°C, cosubstrate adipylCoA
Rattus norvegicus
0.18
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.26
-
Glutarate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
0.26
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
0.27
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.28
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.33
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate adipate
Rattus norvegicus
0.38
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.39
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate succinate or glutarate, reverse reaction
Rattus norvegicus
0.39
-
adipate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
0.4
-
adipyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.45
-
Glutarate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
0.45
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.5
-
Glutarate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA
Rattus norvegicus
0.5
-
succinate
pH 7.8, 30°C, cosubstrate glutarylCoA
Rattus norvegicus
0.52
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.55
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.62
-
3-hydroxy-3-methylglutaryl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate, reverse reaction
Rattus norvegicus
0.65
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.68
-
succinate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
0.7
-
malonyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.72
-
adipate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
0.72
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate glutarate or adipate
Rattus norvegicus
0.73
-
glutaryl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.74
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate
Rattus norvegicus
0.75
-
succinylCoA
pH 7.8, 30°C, cosubstrate malonate
Rattus norvegicus
0.76
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
0.83
-
adipate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
0.83
-
succinyl-CoA
pH 7.8, 30°C, cosubstrate methylmalonate
Rattus norvegicus
0.84
-
Glutarate
pH 7.8, 30°C, cosubstrate methylmalonylCoA
Rattus norvegicus
0.87
-
methylmalonyl-CoA
pH 7.8, 30°C, cosubstrate succinate
Rattus norvegicus
0.88
-
succinate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
0.95
-
succinate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
1.01
-
malonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction
Rattus norvegicus
1.2
-
succinate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
1.25
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
1.32
-
adipate
pH 7.8, 30°C, cosubstrate succinylCoA
Rattus norvegicus
1.42
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
1.51
-
adipate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
1.55
-
malonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
1.63
-
malonate
pH 7.8, 30°C, cosubstrate succinyl-CoA or methylmalonyl-CoA
Rattus norvegicus
1.71
-
malonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
1.8
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate malonyl-CoA
Rattus norvegicus
1.95
-
methylmalonate
pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction
Rattus norvegicus
2.2
-
methylmalonate
pH 7.8, 30°C, cosubstrate malonylCoA
Rattus norvegicus
2.33
-
3-hydroxy-3-methylglutarate
pH 7.8, 30°C, cosubstrate methylmalonyl-CoA
Rattus norvegicus
2.44
-
methylmalonate
pH 7.8, 30°C, cosubstrate glutaryl-CoA
Rattus norvegicus
2.7
-
methylmalonate
pH 7.8, 30°C, cosubstrate succinyl-CoA
Rattus norvegicus
3.05
-
methylmalonate
pH 7.8, 30°C, cosubstrate adipyl-CoA
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Rattus norvegicus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
succinyl-CoA + 3-hydroxy-3-methylglutarate
Rattus norvegicus
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
Rattus norvegicus
r
Purification (Commentary) (protein specific)
Commentary
Organism
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxy-3-methylglutaryl-CoA + adipate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + glutarate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + glutaryl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + malonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
3-hydroxy-3-methylglutaryl-CoA + succinate
-
643834
Rattus norvegicus
3-hydroxy-3-methylglutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + 3-hydroxy-3-methylglutarate
adipyl-CoA shows highest apparent affinty, forward reaction at 64%, reverse reaction at 32% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + glutarate
forward reaction at 82%, reverse reaction at 68% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + glutaryl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + malonate
forward reaction at 40%, reverse reaction at 43% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
adipate + malonyl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + methylmalonate
poor substrate, succinyl-CoA, glutaryl-CoA, malonyl-CoA or 3-hydroxy-3-methylglutaryl-CoA can replace adipyl-CoA
643834
Rattus norvegicus
adipate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
adipyl-CoA + succinate
best substrates, reverse reaction at 38% the rate of forward reaction
643834
Rattus norvegicus
adipate + succinyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + 3-hydroxy-3-methylglutarate
forward and reverse reaction at 50% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + adipate
-
643834
Rattus norvegicus
glutarate + adipyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + malonate
forward reaction at 33%, reverse reaction at 41% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
glutarate + malonyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + methylmalonate
-
643834
Rattus norvegicus
glutarate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
glutaryl-CoA + succinate
-
643834
Rattus norvegicus
glutarate + succinyl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + 3-hydroxy-3-methylglutarate
forward reaction at 34%, reverse reaction at 23% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
malonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + adipate
-
643834
Rattus norvegicus
malonate + adipyl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + glutarate
-
643834
Rattus norvegicus
malonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + methylmalonate
-
643834
Rattus norvegicus
malonate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
malonyl-CoA + succinate
-
643834
Rattus norvegicus
malonate + succinyl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
methylmalonate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + adipate
-
643834
Rattus norvegicus
methylmalonate + adipyl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + glutarate
-
643834
Rattus norvegicus
methylmalonate + glutaryl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + malonate
-
643834
Rattus norvegicus
methylmalonate + malonyl-CoA
-
643834
Rattus norvegicus
r
methylmalonyl-CoA + succinate
-
643834
Rattus norvegicus
methylmalonate + succinyl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
-
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + 3-hydroxy-3-methylglutarate
involved in regulation of the tricarboxylic acid cycle rate and ketogenesis
643834
Rattus norvegicus
succinate + 3-hydroxy-3-methylglutaryl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + adipate
-
643834
Rattus norvegicus
succinate + adipyl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + glutarate
forward reaction at 58%, reverse reaction at 55% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + glutaryl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + malonate
forward reaction at 29%, reverse reaction at 22% the rate of the CoA-transfer between adipyl-CoA and succinate
643834
Rattus norvegicus
succinate + malonyl-CoA
-
643834
Rattus norvegicus
r
succinyl-CoA + methylmalonate
-
643834
Rattus norvegicus
succinate + methylmalonyl-CoA
-
643834
Rattus norvegicus
r
Other publictions for EC 2.8.3.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738808
Marlaire
C7orf10 encodes succinate-hydr ...
Homo sapiens
J. Inherit. Metab. Dis.
37
13-19
2014
-
-
1
-
1
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643834
Deana
Substrate specificity of a dic ...
Rattus norvegicus
Biochem. Int.
26
767-773
1992
-
-
-
-
-
-
-
56
1
-
-
1
-
1
-
-
1
-
-
1
-
-
32
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
56
1
-
-
1
-
-
-
1
-
1
-
-
32
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643833
Francesconi
Further purification and chara ...
Rattus norvegicus
Biochim. Biophys. Acta
999
163-170
1989
1
-
-
-
-
-
14
4
1
-
1
1
-
1
-
-
1
-
-
1
1
1
2
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
14
-
4
1
-
1
1
-
-
-
1
-
1
1
1
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
643832
Deana
Submitochondrial localization ...
Rattus norvegicus
Biochim. Biophys. Acta
662
119-124
1981
1
-
-
-
-
2
3
3
1
-
1
1
-
1
-
-
1
-
-
1
1
1
3
-
-
-
-
-
1
-
1
-
3
-
-
1
-
-
-
-
-
2
-
3
3
3
1
-
1
1
-
-
-
1
-
1
1
1
3
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-