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Literature summary for 2.8.3.12 extracted from

  • Klees, A.G.; Buckel, W.
    Synthesis and properties of (R)-2-hydroxyglutaryl-1-CoA. (R)-2-hydroxyglutaryl-5-CoA, an erroneous product of glutaconate CoA-transferase (1991), Biol. Chem. Hoppe-Seyler, 372, 319-324.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.035
-
(R)-2-hydroxyglutaryl-1-CoA pH 7, 37°C, cosubstrate acetate Acidaminococcus fermentans

Organism

Organism UniProt Comment Textmining
Acidaminococcus fermentans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + (E)-glutaconate
-
Acidaminococcus fermentans acetate + glutaconyl-1-CoA only 1-isomer is formed ?
acetyl-CoA + (R)-2-hydroxyglutarate
-
Acidaminococcus fermentans acetate + (R)-2-hydroxyglutaryl-1-CoA in vitro formation of both isomers: (R)-2-hydroxyglutaryl-1-CoA and (R)-2-hydroxyglutaryl-5-CoA, the 1-isomer is kinetically favoured, the 5-isomer is thermodynamically favoured r
acetyl-CoA + (R)-2-hydroxyglutarate
-
Acidaminococcus fermentans acetate + (R)-2-hydroxyglutaryl-1-CoA product in vivo, 5-isomer only occurs in vitro, (R)-2-hydroxyglutaryl-1-CoA is an excellent substrate in the reverse reaction r
glutaconyl-CoA + (R)-2-hydroxyglutarate
-
Acidaminococcus fermentans glutaconate + (R)-2-hydroxyglutaryl-CoA formation of the 5-isomer, not of the 1-isomer ?
additional information no substrate: lactone-CoA Acidaminococcus fermentans ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Acidaminococcus fermentans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Acidaminococcus fermentans