Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetate | - |
Klebsiella aerogenes |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
(3S)-citryl-CoA | pH 8.0, 25°C | Klebsiella aerogenes | |
1.3 | - |
acetyl-CoA | pH 8.0, 25°C, isolated transferase | Klebsiella aerogenes | |
1.3 | - |
butyryl-CoA | pH 8.0, 25°C, isolated transferase | Klebsiella aerogenes | |
1.3 | - |
propionyl-CoA | pH 8.0, 25°C, isolated transferase | Klebsiella aerogenes | |
1.3 | - |
acetyl-dephospho-CoA | pH 8.0, 25°C, isolated transferase | Klebsiella aerogenes | |
3.3 | - |
propionyl-CoA | pH 8.0, 25°C, integrated into deacetyl citrate lyase | Klebsiella aerogenes | |
6.7 | - |
acetyl-CoA | pH 8.0, 25°C, integrated into deacetyl citrate lyase | Klebsiella aerogenes | |
12.5 | - |
acetyl-dephospho-CoA | pH 8.0, 25°C, integrated into deacetyl citrate lyase | Klebsiella aerogenes |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + citrate | Klebsiella aerogenes | biologically significant reaction of transferase subunit as part of citrate lyase, the isolated transferase subunit represents not only an acetyl-thioacyl carrier protein, citrate acyl carrier protein transferase but also an acetyl-CoA:citrate CoA-transferase | acetate + (3S)-citryl-CoA | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella aerogenes | - |
ATCC 13882 | - |
Purification (Comment) | Organism |
---|---|
complete EC 4.1.3.6 citrate lyase with 3 subunits, EC 2.8.3.10 is the largest subunit | Klebsiella aerogenes |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
9.1 | - |
acetyl-CoA, integrated into enzyme complex | Klebsiella aerogenes |
25 | - |
acetyl-CoA, isolated transferase subunit | Klebsiella aerogenes |
Storage Stability | Organism |
---|---|
-70°C, stable | Klebsiella aerogenes |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + citrate | - |
Klebsiella aerogenes | acetate + (3S)-citryl-CoA | - |
r | |
acetyl-CoA + citrate | biologically significant reaction of transferase subunit as part of citrate lyase, the isolated transferase subunit represents not only an acetyl-thioacyl carrier protein, citrate acyl carrier protein transferase but also an acetyl-CoA:citrate CoA-transferase | Klebsiella aerogenes | acetate + (3S)-citryl-CoA | - |
r | |
acetyl-dephospho-CoA + citrate | - |
Klebsiella aerogenes | acetate + (3S)-citryl-dephospho-CoA | - |
r | |
acetyl-[acyl-carrier protein] + citrate | - |
Klebsiella aerogenes | acetate + (3S)-citryl-[acyl-carrier protein] | - |
r | |
butyryl-CoA + citrate | - |
Klebsiella aerogenes | butyrate + (3S)-citryl-CoA | - |
r | |
additional information | also catalyzes a citrate independent exchange reaction of acetyl residues between acetyl-thioacyl carrier protein or acetyl-CoA and acetate | Klebsiella aerogenes | ? | - |
? | |
propionyl-CoA + citrate | - |
Klebsiella aerogenes | propionate + (3S)-citryl-CoA | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21.7 | - |
acetyl-CoA | pH 8.0, 25°C | Klebsiella aerogenes | |
26.7 | - |
(3S)-citryl-CoA | pH 8.0, 25°C | Klebsiella aerogenes |