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Literature summary for 2.8.2.8 extracted from

  • Dou, W.; Xu, Y.; Pagadala, V.; Pedersen, L.C.; Liu, J.
    Role of deacetylase activity of N-deacetylase/n-sulfotransferase 1 in forming n-sulfated domain in heparan sulfate (2015), J. Biol. Chem., 290, 20427-20437.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by EDTA Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information divalent metal ions are not required for N-sulfotransferase activity of NDST-1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P52848
-
-

Purification (Commentary)

Purification (Comment) Organism
heparin-Toyopearl column chromatography and nickel-agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
additional information NDST-1 is a bifunctional enzyme that displays N-deacetylase and N-sulfotransferase activities to convert an N-acetylated glucosamine residue to an N-sulfoglucosamine residue Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
N-deacetylase/N-sulfotransferase 1
-
 Homo sapiens
NDST-1
-
 Homo sapiens