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Literature summary for 2.8.2.5 extracted from
- Stimulation of glycosaminoglycan sulfotransferase from chick embryo cartilage by basic proteins and polyamines (1980), Biochim. Biophys. Acta, 616, 208-217.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | stimulation by basic substances is much higher than that by Mn2+, however increasing Mn2+ concentration immediately reduces the stimulation by basic substances | Gallus gallus | |
| protamine | stimulates | Gallus gallus |  |
| protamine | molar ratio of protamine to repeating disaccharide unit of chondroitin is 1:100 | Gallus gallus | |
| spermine | stimulates | Gallus gallus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Gallus gallus | |
| ATP | - |
Gallus gallus | |
| EDTA | - |
Gallus gallus | |
| heparin | - |
Gallus gallus | |
| Oversulfated glucosaminoglycan | - |
Gallus gallus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Gallus gallus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | stimulates | Gallus gallus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + chondroitin | Gallus gallus | - |
adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | embryonic | Gallus gallus | - |
| cartilage | epiphyseal | Gallus gallus | - |
| cornea | - |
Gallus gallus | - |
| embryo | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + chondroitin | - |
Gallus gallus | adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Gallus gallus |
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Release 2023.1 (January 2023)
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