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Literature summary for 2.8.2.4 extracted from

  • Narukawa, Y.; Niimura, A.; Noguchi, H.; Tamura, H.; Kiuchi, F.
    New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L. (2014), J. Nat. Med., 68, 125-131.
    View publication on PubMed
Search for more literature for 2.8.2.4

Inhibitors

Inhibitors Comment Organism Structure
(+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
-
 Homo sapiens
(+)-hispanone
-
 Homo sapiens
(-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one
-
 Homo sapiens
leosibiric acid A most potent inhibition Homo sapiens
leosibiric acid B
-
 Homo sapiens
Meclofenamic acid
-
 Homo sapiens
additional information not inhibited by isoleoheterin, (-)-8n-acetoxy-15,16-epoxy-8,9-seco-13(16),14-labdadiene-7,9-dione, (-) hispanolone, (+)-leoheterin, (+)-galeopsin, and (+)-sibiricinone B Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49888
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
E-ST
-
 Homo sapiens
estrogen sulfotransferase
-
 Homo sapiens
SULT1E1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0054
-
 at pH 6.0 and 37°C Homo sapiens Meclofenamic acid
0.0079
-
 at pH 6.0 and 37°C Homo sapiens leosibiric acid A
0.0198
-
 at pH 6.0 and 37°C Homo sapiens (+)-hispanone
0.0232
-
 at pH 6.0 and 37°C Homo sapiens leosibiric acid B
0.0313
-
 at pH 6.0 and 37°C Homo sapiens (+)-6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one
0.0405
-
 at pH 6.0 and 37°C Homo sapiens (-)-6,9:15,16-diepoxy-9alpha-hydroxy-8,9-seco-13(16),14-labdadiene-7-one