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Literature summary for 2.8.2.4 extracted from

  • Cole, G.B.; Keum, G.; Liu, J.; Small, G.W.; Satyamurthy, N.; Kepe, V.; Barrio, J.R.
    Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates (2010), Proc. Natl. Acad. Sci. USA, 107, 6222-6227.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.4

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000006
-
 17beta-estradiol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00012
-
 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00025
-
 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00043
-
 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00052
-
 2-(4-iodophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00056
-
 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00077
-
 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.0009
-
 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00099
-
 2-phenyl-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.001
-
 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00132
-
 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00142
-
 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00142
-
 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00211
-
 2-(4-aminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00236
-
 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus
0.00591
-
 2-naphthol in 50 mM Tris-HCl, pH 7.4, at 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine-3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 17beta-estradiol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1H-indol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-naphthol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the majority of the SULT1E1 activity is observed in the frontal cortical area, superior cortical areas, subcortical areas, and brain stem Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine-3',5'-bisphosphate + 1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1,3-benzoxazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1,3-benzoxazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzofuran-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzofuran-5-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzofuran-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzofuran-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzothiophene-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzothiophene-5-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1-benzothiophene-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-benzothiophene-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?
3'-phosphoadenylyl sulfate + 1H-indol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1H-indol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-aminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-aminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-cyanophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-dimethylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-iodophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-iodophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methoxyphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylamino-3-fluorophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-5-yl suflate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-methylsulfonylphenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-N-acetylaminophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-(4-nitrophenyl)-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-5-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-methyl-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-methyl-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-naphthol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-phenyl-1,3-benzothiazol-6-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-phenyl-1,3-benzothiazol-6-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-[4-dimethylaminophenyl]-1,3-benzothiazol-5-yl sulfate
-
 ?

Synonyms

Synonyms Comment Organism
EST
-
 Rattus norvegicus
estrogen sulfotransferase
-
 Rattus norvegicus
SULT1E1
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function SULT1E1 is a key enzyme in estrogen homeostasis Rattus norvegicus