Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + 17beta-estradiol | Mus musculus | - |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
epididymis | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
white adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + 17beta-estradiol | - |
Mus musculus | adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EST | - |
Mus musculus |
estrogen sulfotransferase | - |
Mus musculus |
sulfotransferase 1E1 | - |
Mus musculus |
SULT1E1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | enzyme expression is dramatically reduced in differentiated 3T3-L1 cells and mature primary adipocytes | down |
General Information | Comment | Organism |
---|---|---|
malfunction | ablation of the enzyme accelerates the differentiation of primary preadipocytes | Mus musculus |
physiological function | estrogen sulfotransferase activity inhibits adipocyte differentiation. Enzyme overexpression in the adipose tissue of female transgenic mice results in smaller adipocyte size. Enzyme overexpression results in a sustained activation of ERK1/2 (p42/p44) MAPK and attenuates the insulin-signaling pathway | Mus musculus |