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Literature summary for 2.8.2.4 extracted from

  • Wada, T.; Ihunnah, C.A.; Gao, J.; Chai, X.; Zeng, S.; Philips, B.J.; Rubin, J.P.; Marra, K.G.; Xie, W.
    Estrogen sulfotransferase inhibits adipocyte differentiation (2011), Mol. Endocrinol., 25, 1612-1623.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + 17beta-estradiol Mus musculus
-
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57BL/6J
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-
adipocyte
-
Mus musculus
-
epididymis
-
Mus musculus
-
testis
-
Mus musculus
-
white adipose tissue
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + 17beta-estradiol
-
Mus musculus adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
?

Synonyms

Synonyms Comment Organism
EST
-
Mus musculus
estrogen sulfotransferase
-
Mus musculus
sulfotransferase 1E1
-
Mus musculus
SULT1E1
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is dramatically reduced in differentiated 3T3-L1 cells and mature primary adipocytes down

General Information

General Information Comment Organism
malfunction ablation of the enzyme accelerates the differentiation of primary preadipocytes Mus musculus
physiological function estrogen sulfotransferase activity inhibits adipocyte differentiation. Enzyme overexpression in the adipose tissue of female transgenic mice results in smaller adipocyte size. Enzyme overexpression results in a sustained activation of ERK1/2 (p42/p44) MAPK and attenuates the insulin-signaling pathway Mus musculus