Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme inactivates estrogen through sulfoconjugation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Mus musculus | - |
heart | low expression | Mus musculus | - |
kidney | low expression | Mus musculus | - |
lung | - |
Mus musculus | - |
macrophage | high expression | Mus musculus | - |
additional information | not detected in brain, intestine, liver, ovary, uterus, and stomach | Mus musculus | - |
parametrial fat | highest expression | Mus musculus | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme inactivates estrogen through sulfoconjugation | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EST | - |
Mus musculus |
estrogen sulfotransferase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | enzyme expression is induced by testosterone in female mice | up |
General Information | Comment | Organism |
---|---|---|
physiological function | estrogen sulfotransferase regulates body fat and glucose homeostasis in female mice. Enzyme overexpression decreases the differentiation of primary adipocytes, and this is associated with reductions in the expression of peroxisome proliferator-activated receptor-gamma, fatty acid synthase, hormone-sensitive lipase, lipoprotein lipase, and leptin | Mus musculus |