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Literature summary for 2.8.2.4 extracted from
- Steroid sulfatase and estrogen sulfotransferase in human carcinomas (2011), Mol. Cell. Endocrinol., 340, 148-153.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme immunoreactivity is inversely correlated with tumor size or lymph node status in the invasive breast carcinoma, and is also significantly associated with a decreased risk of recurrence or improved prognosis of the patients. Ovarian cancer patients with higher enzyme activity are significantly associated with shorter progression-free survival than those with lower enzyme activity | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + estrone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + estrone sulfate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast carcinoma cell | - |
Homo sapiens | - |
| colonic carcinoma cell | - |
Homo sapiens | - |
| endometrial carcinoma cell | - |
Homo sapiens | - |
| additional information | the enzyme is not detected in non-neoplastic prostate tissues | Homo sapiens | - |
| ovarian carcinoma cell | - |
Homo sapiens | - |
| prostate carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + estrone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estrone sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EST | - |
Homo sapiens |
| estrogen sulfotransferase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | enzyme activity is significantly higher in the endometrial carcinoma than in normal endometrial tissues | up |
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Release 2023.1 (January 2023)
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