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Literature summary for 2.8.2.4 extracted from

  • Falany, C.N.; He, D.; Li, L.; Falany, J.L.; Wilborn, T.W.; Kocarek, T.A.; Runge-Morris, M.
    Regulation of hepatic sulfotransferase (SULT) 1E1 expression and effects on estrogenic activity in cystic fibrosis (CF) (2009), J. Steroid Biochem. Mol. Biol., 114, 113-119.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.4

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
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liver
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
EST
-
 Homo sapiens
estrogen-ST
-
 Homo sapiens
sulfotransferase 1E1
-
 Homo sapiens
SULT1E1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the increase in SULT1E1 activity results in the alteration of estradiol-regulated protein expression in cystic fibrosis liver, SULT1E1 expression in HepG2 cells is inducible by sterol mediated liver-X-receptor activation although not by progestins that induce SULT1E1 in the endometrium up

General Information

General Information Comment Organism
physiological function SULT1E1 is responsible for the inactivation of beta-estradiol at physiological concentrations via conjugation with sulfonate Homo sapiens