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Literature summary for 2.8.2.4 extracted from

  • Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.
    Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases (2009), Biochem. J., 422, 455-462.
    View publication on PubMed
Search for more literature for 2.8.2.4

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5,7-dichlorokynurenic acid
-
 Homo sapiens
gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Homo sapiens
Kynurenic acid
-
 Homo sapiens
L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Homo sapiens
L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Homo sapiens
Mefenamic acid
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00033
-
 beta-estradiol isoform SULT1E1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 1-naphthol Homo sapiens
-
 adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
 adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
3'-phosphoadenylyl sulfate + beta-estradiol Homo sapiens
-
 adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + desipramine Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + L-triiodothyronine Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + xanthurenic acid Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49888
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 1-naphthol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
3'-phosphoadenylyl sulfate + beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + desipramine
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl sulfate + xanthurenic acid
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
cytosolic sulfotransferase
-
 Homo sapiens
SULT1E1 isoform Homo sapiens