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Literature summary for 2.8.2.4 extracted from
- Estrogen sulfotransferases in breast and endometrial cancers (2009), Ann. N. Y. Acad. Sci., 1155, 88-98.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3beta-hydroxytibolone | 102% stimulation of activity at 0.0005 mM | Homo sapiens |  |
| celecoxib | - |
Homo sapiens | |
| medrogestone | 85% stimulation of activity at 0.0005 mM | Homo sapiens | |
| nomegestrol acetate | 42% stimulation of activity at 0.0005 mM | Homo sapiens | |
| Promegestone | 31% stimulation of activity at 0.0005 mM | Homo sapiens | |
| quercetin | - |
Homo sapiens | |
| resveratrol | - |
Homo sapiens | |
| tibolone | 41% stimulation of activity at 0.0005 mM | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| resveratrol | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
SULT1E1 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| Human-7 cell | - |
Homo sapiens | - |
| mammary gland | estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell | Homo sapiens | - |
| MCF-7 cell | estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell | Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
| T-47D cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + estradiol | SULT1E1 acts at nanomolar concentration of estradiol. SULT1A1 is active at micromolar concentration of estradiol and has an affinity 300fold lower than SULT1E1 | Homo sapiens | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EST | - |
Homo sapiens |
| estrogen sulfotransferase | - |
Homo sapiens |
| SULT1A1 | active in breast cancer cells | Homo sapiens |
| SULT1E1 | active in normal breast cells | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | SULT expression in breast cancer cells can be stimulated by promegestone, SULT1E1 expression can be controlled by progesterone during the menstrual cycle and during early pregnancy | up |
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