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Literature summary for 2.8.2.4 extracted from

  • Li, L.; He, D.; Wilborn, T.W.; Falany, J.L.; Falany, C.N.
    Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation (2008), Steroids, 74, 20-29.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.4

Cloned(Commentary)

Cloned (Comment) Organism
SULT1E1, expression in Hep-G2 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information IGF-1 message levels in cystic fibrosis transmembrane receptor (CFTR)-deficient mouse livers are positively correlated with body weight and negatively correlated with SULT1E1 activity, overexpression of SULT1E1 reduces STAT5b phosphorylation, pathway regulation, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol Mus musculus inactivation, increased 17beta-estradiol sulfation affects the GH signaling pathway and E2-regulated gene expression, enhanced SULT1E1 activity plays a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of 17beta-estradiol, regulation, overview adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol inactivation Mus musculus adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?
3'-phosphoadenylyl sulfate + 17beta-estradiol inactivation, increased 17beta-estradiol sulfation affects the GH signaling pathway and E2-regulated gene expression, enhanced SULT1E1 activity plays a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of 17beta-estradiol, regulation, overview Mus musculus adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
-
 ?

Synonyms

Synonyms Comment Organism
sulfotransferase 1E1
-
 Mus musculus
SULT1E1
-
 Mus musculus