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Literature summary for 2.8.2.4 extracted from

  • Hudelist, G.; Czerwenka, K.; Keckstein, J.; Haas, C.; Fink-Retter, A.; Gschwantler-Kaulich, D.; Kubista, E.; Singer, C.F.
    Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis (2007), Reprod. Sci., 14, 798-805.
    View publication on PubMed
Search for more literature for 2.8.2.4

Cloned(Commentary)

Cloned (Comment) Organism
EST expression analysis in healthy and endometriosis uterine endometrium showing no significant differences Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + estradiol Homo sapiens estradiol sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone Homo sapiens estrone sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
additional information Homo sapiens EST catalyzes the transfer of a sulfuryl group to estrogens and might be involved in endometriosis, an estrogen-dependent gynecological disease, characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity, causing pelvic pain and infertility. Impaired estrogen metabolism plays a pivotal role in the pathogenesis of the disease, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 females with or without endometriosis
-

Source Tissue

Source Tissue Comment Organism Textmining
uterine endometrium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estradiol estradiol sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone estrone sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
additional information EST catalyzes the transfer of a sulfuryl group to estrogens and might be involved in endometriosis, an estrogen-dependent gynecological disease, characterized by implantation and invasive growth of endometrial tissue outside the uterine cavity, causing pelvic pain and infertility. Impaired estrogen metabolism plays a pivotal role in the pathogenesis of the disease, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
E2-inactivating estrogen sulfotransferase
-
 Homo sapiens
EST
-
 Homo sapiens