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Literature summary for 2.8.2.4 extracted from

  • Svoboda, M.; Thalhammer, T.; Aust, S.; Arrich, F.; Assadian, O.; Toma, C.D.
    Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors (2007), J. Surg. Oncol., 95, 572-581.
    View publication on PubMed
Search for more literature for 2.8.2.4

Cloned(Commentary)

Cloned (Comment) Organism
SULT1E1, quantitative expression analysis in benign and in primary and secondary malignant bone tumors Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol Homo sapiens 17beta-estradiol regulates growth and differentiation in normal and malignant bone, it is inactivated to 17beta-estradiol-sulfate through SULT1E1 adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone cancer cell benign, and primary and secondary malignant bone tumors, from patients undergoing routine surgery for skeletal tumors Homo sapiens
-
bone marrow stromal cells Homo sapiens
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HOS cell an osteosarcoma cell line, increased expression compared to healthy cells Homo sapiens
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MG-63 cell an osteosarcoma cell line, high SULT1E1 expression level Homo sapiens
-
additional information SULT1E1 bone expression levels show no correlation to age Homo sapiens
-
osteoblast
-
 Homo sapiens
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osteosarcoma cell
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 Homo sapiens
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TC-71 cell a Ewingย’s sarcoma cell line, expression level of SULT1E1 is slightly reduced comapred to heathy cells Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + 17beta-estradiol 17beta-estradiol regulates growth and differentiation in normal and malignant bone, it is inactivated to 17beta-estradiol-sulfate through SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
estrogen sulfotransferase
-
 Homo sapiens
SULT1E1
-
 Homo sapiens