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Literature summary for 2.8.2.4 extracted from
- Expression of estrogen-metabolizing enzymes and estrogen receptors in cholelithiasis gallbladder (2008), Biomed. Pharmacother., 62, 690-696.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | SULT1E1 expression is 3-4fold increased in inflamed gallbladder epithelium along with an increased in estrogen receptors, overview | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression analysis of SULT1E1 in gallbladder tissue | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | estrogen exposure is a risk factor for gallstone disease, cholelithiasis, which often leads to chronic inflammation, cholecystitis. SULT1E1 is a key enzymes involved in the inactivation of estrogens. Estrogen concentrations in human gallbladder are regulated by a network of activating STS and inactivating SULT1E1, and estrogen receptors alpha and beta, localization in tissue, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | - |
Homo sapiens | - |
| gall bladder epithelium | from from 14 patients operated for symptomatic cholelithiais | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | estrogen exposure is a risk factor for gallstone disease, cholelithiasis, which often leads to chronic inflammation, cholecystitis. SULT1E1 is a key enzymes involved in the inactivation of estrogens. Estrogen concentrations in human gallbladder are regulated by a network of activating STS and inactivating SULT1E1, and estrogen receptors alpha and beta, localization in tissue, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| estrogen sulfotransferase | - |
Homo sapiens |
| More | SULT1E1 belongs tot he superfamily of cytosolic SULTs | Homo sapiens |
| SULT1E1 | - |
Homo sapiens |
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