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Literature summary for 2.8.2.4 extracted from
- On the sulfation and methylation of catecholestrogens in human mammary epithelial cells and breast cancer cells (2008), Biol. Pharm. Bull., 31, 769-773.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| SULT1E1 expression in a prokaryotic expression system | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate | - |
? |  |
| 3'-phosphoadenylyl sulfate + estrone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
| additional information | Homo sapiens | concerted action of catechol-O-methyltransferase and the cytosolic sulfotransferase, SULT, enzyme(s) in the metabolism of catecholestrogens with production of sulfated 2-methoxy-estrone or sulfated 2- or 4-methoxy-estradiol, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant SULT1E1 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| mammary epithelial cell | - |
Homo sapiens | - |
| MCF-10A cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.012 | - |
purified recombinant SULT1E1 with substrate estrone | Homo sapiens |
| 0.0455 | - |
purified recombinant SULT1E1 with substrate 17beta-estradiol | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + estrone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
| additional information | concerted action of catechol-O-methyltransferase and the cytosolic sulfotransferase, SULT, enzyme(s) in the metabolism of catecholestrogens with production of sulfated 2-methoxy-estrone or sulfated 2- or 4-methoxy-estradiol, overview | Homo sapiens | ? | - |
? | |
| additional information | differential sulfating activities of the human SULTs toward catecholestrogens and nethoxyestrogens, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT1E1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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