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Literature summary for 2.8.2.4 extracted from

  • Maiti, S.; Zhang, J.; Chen, G.
    Redox regulation of human estrogen sulfotransferase (hSULT1E1) (2007), Biochem. Pharmacol., 73, 1474-1481.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.4

Activating Compound

Activating Compound Comment Organism Structure
N-acetylcysteine a GSH inducer, increases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
buthionine sulfoxamine a GSH depletor, decreases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells Homo sapiens
GSSG oxidized glutathione, inactivation and kinetics, adenosine 3'-phosphate 5'-phosphosulfate protects Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol Homo sapiens hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone Homo sapiens hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
additional information Homo sapiens the redox regulation of hSULT1E1 may interrupt the regulation and function of estrogens under various physiological and pathological conditions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + 17beta-estradiol the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
additional information the redox regulation of hSULT1E1 may interrupt the regulation and function of estrogens under various physiological and pathological conditions Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
estrogen sulfotransferase
-
 Homo sapiens
SULT1E1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inactivation kinetics with oxidized glutathione Homo sapiens