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Literature summary for 2.8.2.4 extracted from

  • Furimsky, A.M.; Green, C.E.; Hunt Sharp, L.E.; Catz, P.; Adjei, A.A.; Parman, T.; Kapetanovic, I.M.; Weinshilboum, R.M.; Iyer, L.V.
    Effect of resveratrol on 17{beta}-estradiol sulfation by human hepatic and jejunal S9 and recombinant SULT1E1 (2008), Drug Metab. Dispos., 36, 129-136.
    View publication on PubMed
Search for more literature for 2.8.2.4

Inhibitors

Inhibitors Comment Organism Structure
additional information no effect by 0.1-1.0% v/v ethanol Homo sapiens
resveratrol inhibits estradiol sulfonation, phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000007
-
 ethinyl estradiol pH 7.4, SULT1E1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + estradiol Homo sapiens
-
 adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
additional information Homo sapiens phytoestrogens can potentially alter the homeostasis of estrogen levels ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 female and male
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant SULT1E1 expressed in insect Sf9 cells Homo sapiens
-
intestine
-
 Homo sapiens
-
jejunum S9 fractions Homo sapiens
-
liver S9 fractions Homo sapiens
-
additional information analysis of tissue specific expression of the enzyme, overview Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000000049
-
 recombinant SULT1E1 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phopshoadenylyl sulfate + resveratrol i.e. 3,5,4'-trihydroxystilbene, a phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol, overview Homo sapiens adenosine 3',5'-bisphosphate + resveratrol 3-O-sulfate + resveratrol 4'-O-sulfate + resveratrol 3,4'-O-disulfate three different sulfate products, product identification by NMR, overview ?
3'-phosphoadenylyl sulfate + estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estradiol isozyme SULT1E1 is specific for estradiol sulfonation, interaction of resveratrol with 17beta-estradiol, overview Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + ethinyl estradiol a synthetic oral contraceptive, low activity Homo sapiens adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate
-
 ?
additional information phytoestrogens can potentially alter the homeostasis of estrogen levels Homo sapiens ?
-
 ?
additional information the reaction is also performed by the phenol sulfotranferase, EC 2.8.2.1, but with lower activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
EST
-
 Homo sapiens
estrogen sulfotransferase
-
 Homo sapiens
SULT1E1
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0006
-
 resveratrol pH 7.4, jejunum extract, inhibition of estradiol sulfonation Homo sapiens
0.0011
-
 resveratrol pH 7.4, liver extract, inhibition of estradiol sulfonation Homo sapiens
0.0023
-
 resveratrol pH 7.4, recombinant SULT1E1, inhibition of estradiol sulfonation Homo sapiens