Literature summary for 2.8.2.4 extracted from

Otake, Y.; Nolan, A.L.; Walle, U.K.; Walle, T.
Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells (2000), J. Steroid Biochem. Mol. Biol., 73, 265-270.

Search for more literature for 2.8.2.4

Cloned(Commentary)

Cloned (Comment)	Organism
EST cDNA subcloned into pKK233-2 and expressed in Escherichia coli XL1-Blue	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
quercetin	competitive inhibition	Homo sapiens
resveratrol	competitive inhibition	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00032	-	quercetin	pH 7.4, 37°C	Homo sapiens
0.00058	-	resveratrol	pH 7.4, 37°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelium	mammary epithelial cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylylsulfate + 17beta-estradiol	-	Homo sapiens	adenosine 3',5'-bisphosphate + estradiol 3-sulfate	-	r
3'-phosphoadenylylsulfate + quercetin	-	Homo sapiens	adenosine 3',5'-bisphosphate + quercetin sulfate	-	r
3'-phosphoadenylylsulfate + resveratrol	-	Homo sapiens	adenosine 3',5'-bisphosphate + resveratrol sulfate	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00036	-	resveratrol	pH 7.4, 37°C	Homo sapiens
0.00058	-	quercetin	pH 7.4, 37°C	Homo sapiens

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Release 2023.1 (January 2023)