BRENDA - Enzyme Database
show all sequences of 2.8.2.3

Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases

Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.; Biochem. J. 422, 455-462 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
5,7-dichlorokynurenic acid
-
Mus musculus
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
Kynurenic acid
-
Mus musculus
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
Mefenamic acid
-
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Purification (Commentary)
Commentary
Organism
Ni-NTA agarose column chromatography
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
5,7-dichlorokynurenic acid
-
Mus musculus
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
Kynurenic acid
-
Mus musculus
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
Mefenamic acid
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
Ni-NTA agarose column chromatography
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
Other publictions for EC 2.8.2.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
702138
Senggunprai
Inhibitory effects of kynureni ...
Mus musculus
Biochem. J.
422
455-462
2009
-
-
1
-
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6
-
1
-
-
8
-
1
-
-
1
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-
8
-
-
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-
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-
-
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1
-
-
-
-
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6
-
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1
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8
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690752
Takahashi
Molecular cloning, expression, ...
Mus musculus
Biochem. Biophys. Res. Commun.
375
531-535
2008
-
-
1
-
-
-
-
4
1
-
2
2
-
4
-
-
-
-
-
-
-
-
18
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
4
2
-
2
2
-
-
-
-
-
-
-
-
18
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
645863
Ozawa
Association of genotypes of ca ...
Homo sapiens
Int. J. Cancer
102
418-421
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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1
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1
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-
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-
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-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
645864
Yoshinari
Molecular cloning and expressi ...
Oryctolagus cuniculus
J. Biochem.
123
479-486
1998
-
-
1
-
-
-
-
1
2
-
1
2
-
4
-
-
-
-
-
1
-
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6
-
-
-
-
-
-
-
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-
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1
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-
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1
2
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1
2
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1
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6
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-
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-
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-
-
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-
645862
Maritomi
Isolation and characterization ...
Rattus norvegicus
Biol. Pharm. Bull.
17
1008-1011
1994
-
-
-
-
-
-
-
1
2
-
-
1
-
3
-
-
1
-
-
2
1
-
5
-
-
-
-
-
2
-
-
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-
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-
-
-
-
-
-
-
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-
1
2
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1
-
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1
-
2
1
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
645859
Hernandez
Human liver arylamine N-sulfot ...
Homo sapiens
Drug Metab. Dispos.
19
1071-1079
1991
-
-
-
-
-
-
1
3
1
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
-
1
-
-
-
-
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-
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-
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-
1
-
3
1
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1
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1
-
1
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
645858
Ramaswamy
Amine N-sulfotransferase ...
Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus
J. Biol. Chem.
262
10039-10043
1987
3
-
-
-
-
-
-
6
-
3
3
4
-
4
-
-
1
-
-
9
1
-
15
1
3
-
-
-
6
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
6
-
3
3
4
-
-
-
1
-
9
1
-
15
1
3
-
-
-
6
-
-
-
-
-
-
-
-
-
645860
Yu
Sulfate conjugation of monoami ...
Homo sapiens
J. Neurochem.
45
836-843
1985
-
-
-
-
-
-
-
-
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1
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4
-
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1
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2
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5
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1
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1
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1
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2
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5
-
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1
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-
645861
Roy
The enzymic synthesis of aryl ...
Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus
Biochim. Biophys. Acta
30
193
1958
-
-
-
-
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3
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3
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9
-
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3
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9
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