Literature summary for 2.8.2.29 extracted from

Hwang, J.A.; Kim, Y.; Hong, S.H.; Lee, J.; Cho, Y.G.; Han, J.Y.; Kim, Y.H.; Han, J.; Shim, Y.M.; Lee, Y.S.; Kim, D.H.
Epigenetic inactivation of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 in lung cancer and its role in tumorigenesis (2013), PLoS ONE, 8, e79634.

Search for more literature for 2.8.2.29

Application

Application	Comment	Organism
medicine	enzyme hypermethylation is an independent prognostic indicator for overall survival in node-negative stage I-II non-small cell lung cancer	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	Homo sapiens	-	adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
bronchial epithelial cell	-	Homo sapiens	-
H-1650 cell	-	Homo sapiens	-
H-226 cell	-	Homo sapiens	-
H-23 cell	-	Homo sapiens	-
H-460 cell	-	Homo sapiens	-
H-520 cell	-	Homo sapiens	-
non-small cell lung cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine	-	Homo sapiens	adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate	-	?

Synonyms

Synonyms	Comment	Organism
heparan sulfate (glucosamine) 3-O-sulfotransferase 2	-	Homo sapiens
HS3ST2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme expression in lung cancer cells H460 and H23 inhibits cell migration, invasion, cell proliferation	Homo sapiens

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Release 2023.1 (January 2023)