Literature summary for 2.8.2.29 extracted from

Bui, C.; Ouzzine, M.; Talhaoui, I.; Sharp, S.; Prydz, K.; Coughtrie, M.W.; Fournel-Gigleux, S.
Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells (2010), FASEB J., 24, 436-450.

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Activating Compound

Activating Compound	Comment	Organism	Structure
5-aza-2'-deoxycytidine	exposure of chondrosarcoma cells to the DNA-methyltransferase inhibitor 5-Aza-dc up-regulates expression of 3-OST2 mRNA	Homo sapiens

Application

Application	Comment	Organism
medicine	the results provide evidence for specific epigenetic regulation of 3-OST genes resulting in altered heparan sulfate proteoglycans and point to a defect of heparan sulfate-3-O-sulfation as a factor in cancer progression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chondrosarcoma cell	H-EMC-SS chondrosarcoma cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
3-OST2	-	Homo sapiens
heparan sulfate 3-O-sulfotransferase 2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	exposure of chondrosarcoma cells to 5-aza-2'-deoxycytidine up-regulates expression of 3-OST2 mRNA	up

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Release 2023.1 (January 2023)