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Literature summary for 2.8.2.20 extracted from

  • Westmuckett, A.D.; Hoffhines, A.J.; Borghei, A.; Moore, K.L.
    Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency (2008), Gen. Comp. Endocrinol., 156, 145-153.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.20

Cloned(Commentary)

Cloned (Comment) Organism
isozymes TPST-1 and TPSt-2, geno- and phenotyping of wild-types and mutants Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information isozymes TPST-1 and TPSt-2, generation of single and double knockout mice. Double knockout mice completely lack the ability to sulfate peptidyltyrosine, Tpst2-/- mice show primary hypothyroidism, but that Tpst1-/- mice are euthyroid, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + protein tyrosine Mus musculus
-
 adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozymes TPST-1 and TPST-2
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + protein tyrosine
-
 Mus musculus adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
 ?

General Information

General Information Comment Organism
physiological function tyrosine sulfation is required for normal pulmonary function at birth, and isozyme TPST-2 is required for normal thyroid gland function Mus musculus