Literature summary for 2.8.2.20 extracted from

Ronai, Z.; Witt, H.; Rickards, O.; Destro-Bisol, G.; Bradbury, A.R.; Sahin-Toth, M.
A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2) (2009), Biochem. J., 418, 155-161.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylyl sulfate + trypsinogen tyrosine	Homo sapiens	sulfation of Tyr154 with Asp as important determinant. Mutation D153N, a naturally occuring polymorphisms in African population, results in a complete loss of trypsinogen sulfation, while mutation of Gly151 and Pro155 of the trypsinogen has no effect on enzyme activity. Genotyping of different populations for the substrate polymorphism, overview	adenosine 3',5'-bisphosphate + trypsinogen tyrosine O-sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60704	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + human anionic trypsinogen tyrosine	i.e. serine protease 2, sulfation of Tyr154 facilitated by a unique sequence context which is characteristically found in primate trypsinogens	Homo sapiens	adenosine 3',5'-bisphosphate + trypsinogen tyrosine O-sulfate	-	?
3'-phosphoadenylyl sulfate + trypsinogen tyrosine	sulfation of Tyr154 with Asp as important determinant. Mutation D153N, a naturally occuring polymorphisms in African population, results in a complete loss of trypsinogen sulfation, while mutation of Gly151 and Pro155 of the trypsinogen has no effect on enzyme activity. Genotyping of different populations for the substrate polymorphism, overview	Homo sapiens	adenosine 3',5'-bisphosphate + trypsinogen tyrosine O-sulfate	-	?

Synonyms

Synonyms	Comment	Organism
TPST	-	Homo sapiens
tyrosylprotein sulfotransferase	-	Homo sapiens

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Release 2023.1 (January 2023)