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Literature summary for 2.8.2.20 extracted from

  • Yu, Y.; Hoffhines, A.J.; Moore, K.L.; Leary, J.A.
    Determination of the sites of tyrosine O-sulfation in peptides and proteins (2007), Nat. Methods, 4, 583-588.
    View publication on PubMed
Search for more literature for 2.8.2.20

Localization

Localization Comment Organism GeneOntology No. Textmining
trans-Golgi network in the trans-Golgi network the TPST is anchored to the membrane with its catalytic domain luminally oriented Homo sapiens 5802
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + protein tyrosine Homo sapiens tyrosine O-sulfation is a key post-translational modification that regulates protein-protein interactions in extracellular space adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
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Organism

Organism UniProt Comment Textmining
Homo sapiens O60507
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Homo sapiens O60704
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + EDYDTTTEFDsYGD G protein-coupled receptor, human chemokine receptor 1, amino acids 8-20 Homo sapiens adenosine 3',5'-bisphosphate + EDsYDTTTEFDsYGD
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3'-phosphoadenylyl sulfate + EDYDTTTEFDYGD G protein-coupled receptor human chemokine receptor 1, amino acids 8-20 Homo sapiens adenosine 3',5'-bisphosphate + EDYDTTTEFDsYGD
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3'-phosphoadenylyl sulfate + ENYSYDLDYYS G protein-coupled receptor human gpr1, amino acids 13-23, sulfation order: first Tyr21, second Tyr22, third Tyr15 or 17, fourth Tyr 15 or 17 Homo sapiens adenosine 3',5'-bisphosphate + ENsYSsYDLDsYsYS
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3'-phosphoadenylyl sulfate + protein tyrosine
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 Homo sapiens adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
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3'-phosphoadenylyl sulfate + protein tyrosine tyrosine O-sulfation is a key post-translational modification that regulates protein-protein interactions in extracellular space Homo sapiens adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
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3'-phosphoadenylyl sulfate + QATEYEYLDYDFLPE human PSGL-1, amino acids 42-56, sulfation order: first Tyr51, second Tyr46 or 48, third Tyr46 or 48 Homo sapiens adenosine 3',5'-bisphosphate + QATEsYEsYLDsYDFLPE
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3'-phosphoadenylyl sulfate + SYGDEYPDYLD G protein-coupled receptor human dez, amino acids 13-23, sulfation order: first Tyr21, second Tyr18, third Tyr14 Homo sapiens adenosine 3',5'-bisphosphate + SsYGDEsYPDsYLD
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3'-phosphoadenylyl sulfate + TTFFDsYDYGA G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30 Homo sapiens adenosine 3',5'-bisphosphate + TTFFDsYDsYGA
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3'-phosphoadenylyl sulfate + TTFFDYDsYGA G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30 Homo sapiens adenosine 3',5'-bisphosphate + TTFFDsYDsYGA
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3'-phosphoadenylyl sulfate + TTFFDYDYGA G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30 Homo sapiens adenosine 3',5'-bisphosphate + TTFFDsYDYGA
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3'-phosphoadenylyl sulfate + TTFFDYDYGA G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30 Homo sapiens adenosine 3',5'-bisphosphate + TTFFDYDsYGA
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3'-phosphoadenylyl sulfate + vitronectin peptide amino acids 75-91, Y(SO3H)TVY(SO3H)DDGEEKNDATVHE Homo sapiens adenosine 3',5'-bisphosphate + vitronectin-O-sulfate
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3'-phosphoadenylyl sulfate + VTDsYsYYPDI Tyr16-sulfated G protein-coupled receptor CCR8, amino acids 12-20 Homo sapiens adenosine 3',5'-bisphosphate + VTDsYsYsYPDI
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3'-phosphoadenylyl sulfate + VTDYsYYPDI Tyr16-sulfated G protein-coupled receptor CCR8, amino acids 12-20 Homo sapiens adenosine 3',5'-bisphosphate + VTDsYsYYPDI
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3'-phosphoadenylyl sulfate + VTDYYsYPDI both isoenzymes sequentially sulfate the CCR8 peptide such that Tyr15 is sulfated first followed by Tyr17 sulfation Homo sapiens adenosine 3',5'-bisphosphate + VTDsYYsYPDI
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3'-phosphoadenylyl sulfate + VTDYYYPDI a peptide modeled on the N-terminal extracellular domain of human CCR8, amino acids 12-20 Homo sapiens adenosine 3',5'-bisphosphate + VTDYYsYPDI
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Synonyms

Synonyms Comment Organism
TPST
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 Homo sapiens
TPST-1
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 Homo sapiens
TPST-2
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 Homo sapiens
tyrosylprotein sulfotransferase
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 Homo sapiens