Literature summary for 2.8.2.20 extracted from

Seibert, C.; Veldkamp, C.T.; Peterson, F.C.; Chait, B.T.; Volkman, B.F.; Sakmar, T.P.
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases (2008), Biochemistry, 47, 11251-11262.

Search for more literature for 2.8.2.20

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293T cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4	Homo sapiens	CXCR4 signaling is indispensable for embryonic development	adenosine 3',5'-bisphosphate + ?	-	?
3'-phosphoadenylyl sulfate + protein tyrosine	Homo sapiens	-	adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60507	-	-
Homo sapiens	O60704	-	-

Purification (Commentary)

Purification (Comment)	Organism
anti-protein C immunoaffinity chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4	CXCR4 signaling is indispensable for embryonic development	Homo sapiens	adenosine 3',5'-bisphosphate + ?	-	?
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4	CXCR4	Homo sapiens	adenosine 3',5'-bisphosphate + ?	-	?
3'-phosphoadenylyl sulfate + CXCR4 1-38	CC-chemokine receptor 4 peptide, amino acids 1-38	Homo sapiens	adenosine 3',5'-bisphosphate + ?	the enzyme has a strong site preference for sulfation of Tyr-21 over Tyr-7 and Tyr-12, sulfation of Tyr-21 is required for high-affinity interaction with stromal cell-derived factor-1 (SDF-1alpha)	?
3'-phosphoadenylyl sulfate + protein tyrosine	-	Homo sapiens	adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate	-	?
3'-phosphoadenylyl sulfate + QATEYEYLDYDFLPE-NH2	P-selectin glycoprotein ligand-1, amino acids 1-15	Homo sapiens	adenosine 3',5'-bisphosphate + ?	-	?

Synonyms

Synonyms	Comment	Organism
TPST-1	-	Homo sapiens
TPST-2	-	Homo sapiens
tyrosylprotein sulfotransferase	-	Homo sapiens

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Release 2023.1 (January 2023)