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Literature summary for 2.8.2.20 extracted from

  • Borghei, A.; Ouyang, Y.B.; Westmuckett, A.D.; Marcello, M.R.; Landel, C.P.; Evans, J.P.; Moore, K.L.
    Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility (2006), J. Biol. Chem., 281, 9423-9431.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.20

Cloned(Commentary)

Cloned (Comment) Organism
isozymes TPST-1 and TPST-2, genotyping Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information targeted disruption of TPST-2, but not of TPST-1, causes male infertility, the reproductive performance of femal and male mice is reduced in TPST-2-/- mice, Tpst-1-/- males that have normal fertility, while Tpst-2-/- males are infertile, adhesion of Tpst2-/- sperm to the egg plasma membrane is reduced compared with wild type sperm, phenotypes, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane
-
 Mus musculus 139
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus TPST-2 catalyzes post-translational protein tyrosine O-sulfation, TPST-2, but not TPST-1, deficiency causes male infertility ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozymes TPST-1 and TPST-2
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis cauda Mus musculus
-
spleen
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TPST-2 catalyzes post-translational protein tyrosine O-sulfation, TPST-2, but not TPST-1, deficiency causes male infertility Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
tyrosylprotein sulfotransferase-2
-
 Mus musculus