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Literature summary for 2.8.2.20 extracted from

  • Moore, K.L.
    The biology and enzymology of protein tyrosine O-sulfation (2003), J. Biol. Chem., 278, 24243-24246.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Mammalia 5794
-
Golgi apparatus
-
Drosophila melanogaster 5794
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VYB7 only 1 isoform
-
Homo sapiens
-
-
-
Mammalia
-
isoforms TPST1 and TPST2
-
no activity in prokaryotes
-
-
-
no activity in yeast
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + acidic polypeptide tyrosine
-
Homo sapiens adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
?
3'-phosphoadenylylsulfate + acidic polypeptide tyrosine dominant characteristic is that there are generally between 3 and 4 acidic amino acids within the +/-5 residues of the sulfotyrosine Mammalia adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
?
3'-phosphoadenylylsulfate + acidic polypeptide tyrosine dominant characteristic is that there are generally between 3 and 4 acidic amino acids within the +/-5 residues of the sulfotyrosine Drosophila melanogaster adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
?
3'-phosphoadenylylsulfate + C4 alpha chain more efficiently sulphated by TPST1 than TPST2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + heparin cofactor II more efficiently sulphated by TPST1 than TPST2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?