Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O35400 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hepa1-6 cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + cholesterol | - |
Mus musculus | adenosine 3',5'-bisphosphate + cholesterol sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cholesterol sulfotransferase | - |
Mus musculus |
SULT2B1b | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression of SULT2B1b in the liver is induced in obese mice and during the transition from the fasted to the fed state | up |
General Information | Comment | Organism |
---|---|---|
metabolism | isoform SULT2B1b and its enzymatic by-product cholesterol sulfate are important metabolic regulators that control glucose metabolism. Mechanistically, cholesterol sulfate and SULT2B1b inhibit gluconeogenesis by suppressing the expression of acetyl coenzyme A synthetase, leading to decreased acetylation and nuclear exclusion of hepatocyte nuclear factor 4alpha. | Mus musculus |