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Literature summary for 2.8.2.2 extracted from

  • Wang, Z.; Yang, X.; Chen, L.; Zhi, X.; Lu, H.; Ning, Y.; Yeong, J.; Chen, S.; Yin, L.; Wang, X.; Li, X.
    Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury (2016), Arch. Toxicol., 91, 271-287.
    View publication on PubMed
Search for more literature for 2.8.2.2

Organism

Organism UniProt Comment Textmining
Mus musculus O35400
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic oval cell
-
 Mus musculus
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WB-F344 cell
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 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + 22-hydroxycholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + 22-hydroxycholesterol sulfate
-
 ?
3'-phosphoadenylylsulfate + 24,25-epoxycholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + 24,25-epoxycholesterol sulfate
-
 ?
3'-phosphoadenylylsulfate + 25-hydroxycholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + 25-hydroxycholesterol sulfate
-
 ?

Synonyms

Synonyms Comment Organism
hydroxysteroid sulfotransferase 2B1b
-
 Mus musculus
SULT2B1b
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression of SULT2B1b is increased dramatically in a chemical-induced liver injury model, mainly in hepatic oval cells up

General Information

General Information Comment Organism
physiological function upregulation of SULT2B1b promotes hepatic oval cell proliferation and aggravate liver injury via the suppression of oxysterol-induced LXR activation in chemically induced mouse liver injury Mus musculus