Literature summary for 2.8.2.2 extracted from

Chen, X.; Zhang, J.; Baker, S.M.; Chen, G.
Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) (2007), Toxicology, 231, 224-233.

Search for more literature for 2.8.2.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	methotrexate and 6-(4-chlorophenyl)imidazo [2,1-b][1,3] thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime induction of hSULT2A1 through interacting with androstane receptor and retinoid X receptor alpha mediated by the IR2 element, mechanism, overview	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
SULT2A1, expression in Caco-2 cells and analysis of the transcriptional regulation mechanism of hSULT2A1 promoter, quantitative enzyme expression analysis. Constitutive androstane receptor and retinoid X receptor alpha are involved in the transcriptional regulation of hSULT2A1, overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	SULT2A1 downreguletion by siRNA, and progressive promoter deletion, expression analysis. An IR2 element of the hSULT2A1 promoter region mediates the methotrexate induction of hSULT2A1 through interacting with androstane receptor and retinoid X receptor alpha	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylyl sulfate + dehydroepiandrosterone	Homo sapiens	the sulfation, catalyzed by SULT, is important in the regulation of biological activities of hormones and neurotransmitters, the metabolism of drugs, and the detoxification of xenobiotic toxicants. Sulfation also leads to the bioactivation of procarcinogens. Human SULT2A1 is a major sulfotransferase catalyzing the sulfation of hydroxysteroids and xenobiotic alcohols, mechanisms controlling the regulation of hSULT2A1, overview	adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q06520	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylyl sulfate + dehydroepiandrosterone	the sulfation, catalyzed by SULT, is important in the regulation of biological activities of hormones and neurotransmitters, the metabolism of drugs, and the detoxification of xenobiotic toxicants. Sulfation also leads to the bioactivation of procarcinogens. Human SULT2A1 is a major sulfotransferase catalyzing the sulfation of hydroxysteroids and xenobiotic alcohols, mechanisms controlling the regulation of hSULT2A1, overview	Homo sapiens	adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate	-	?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone	i.e. PAPS and DHEA	Homo sapiens	adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate	-	?

Synonyms

Synonyms	Comment	Organism
dehydroepiandrosterone sulfotransferase	-	Homo sapiens
SULT2A1	-	Homo sapiens

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Release 2023.1 (January 2023)