Literature summary for 2.8.2.2 extracted from

Faucher, F.; Lacoste, L.; Luu-The, V.
Human type 1 estrogen sulfotransferase: catecholestrogen metabolism and potential involvement in cancer promotion (2002), Ann. N. Y. Acad. Sci., 963, 221-228.

Search for more literature for 2.8.2.2

Application

Application	Comment	Organism
medicine	hEST1 involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylylsulfate + dehydroepiandrosterone	Homo sapiens	catalyzes sulfonation of exogenous products like drugs and xenobiotics as well as endogenous compounds such as steroids and bile acids by transferring a sulfonate moiety from the cofactor 3'-phosphoadenosine-5'-phosphosulfate to a hydroxyl group of the substrate, this leads to detoxification or elimination because sulfation increases the hydrophilicity of chemical compounds and therefore their excretion, hEST1 also involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens	adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylylsulfate + 2-hydroxy-catecholestrogen	best substrate for this enzyme, also catalyzes the transformation of 4-hydroxy-estrogens and 16-hydroxy-estrogens, but with a lower affinity	Homo sapiens	adenosine 3',5'-bisphosphate + ?	-	r
3'-phosphoadenylylsulfate + dehydroepiandrosterone	-	Homo sapiens	adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate	-	r
3'-phosphoadenylylsulfate + dehydroepiandrosterone	catalyzes sulfonation of exogenous products like drugs and xenobiotics as well as endogenous compounds such as steroids and bile acids by transferring a sulfonate moiety from the cofactor 3'-phosphoadenosine-5'-phosphosulfate to a hydroxyl group of the substrate, this leads to detoxification or elimination because sulfation increases the hydrophilicity of chemical compounds and therefore their excretion, hEST1 also involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens	Homo sapiens	adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate	-	r

Synonyms

Synonyms	Comment	Organism
hEST1	-	Homo sapiens
type 1 estrogen sulfotransferase	-	Homo sapiens

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Release 2023.1 (January 2023)