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Literature summary for 2.8.2.15 extracted from
- Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs) (2006), Steroids, 71, 343-351.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DCNP | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens | |
| 0.00056 | - |
3beta-tibolone | pH 7.0, 37°C, recombinant SULT1A1 | Homo sapiens | |
| 0.00079 | - |
3alpha-tibolone | pH 6.0, 37°C, recombinant SULT1A1 | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activates | Homo sapiens | |
| NaCl | activates | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone | Homo sapiens | sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis | adenosine 3',5'-bisphosphate + 3alpha-hydroxytibolone 3-O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone | Homo sapiens | sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis | adenosine 3',5'-bisphosphate + 3beta-hydroxytibolone 3-O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + dehydroepiandrosterone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
SULT2A1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | postmenopausal, SULT2A1 | Homo sapiens | - |
| small intestine | postmenopausal, SULT2A1 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 3alpha-hydroxytibolone 3-O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone | sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis | Homo sapiens | adenosine 3',5'-bisphosphate + 3alpha-hydroxytibolone 3-O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 3beta-hydroxytibolone 3-O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone | sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis | Homo sapiens | adenosine 3',5'-bisphosphate + 3beta-hydroxytibolone 3-O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT2A1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7 | assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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