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Literature summary for 2.8.2.15 extracted from

  • Harris, R.M.; Kirk, C.J.; Waring, R.H.
    Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenols (2005), Mol. Cell. Endocrinol., 244, 72-74.
    View publication on PubMed
Search for more literature for 2.8.2.15

Inhibitors

Inhibitors Comment Organism Structure
2,3-dichlorophenol IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens
2,4-Dichlorophenol IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens
2,5-dichlorophenol IC50: 0.0022 mM, vs. 10 nM estradiol Homo sapiens
2,6-dichlorophenol IC50: 0.0016 mM, vs. 10 nM estradiol Homo sapiens
2-chlorophenol IC50: 0.02 mM, vs. 10 nM estradiol Homo sapiens
2-phenylphenol IC50: 0.0052 mM, vs. 10 nM estradiol Homo sapiens
3,4-dichlorophenol IC50: 0.013 mM, vs. 10 nM estradiol Homo sapiens
3,5-dichlorophenol IC50: 0.017 mM, vs. 10 nM estradiol Homo sapiens
3-chlorophenol IC50: 0.13 mM, vs. 10 nM estradiol Homo sapiens
4-chloro-3-methylphenol IC50: 0.024 mM, vs. 10 nM estradiol Homo sapiens
4-Chlorophenol IC50: 0.11 mM, vs. 10 nM estradiol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
SULT 1E1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0007
-
 IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens 2,4-Dichlorophenol
0.0007
-
 IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens 2,3-dichlorophenol
0.0016
-
 IC50: 0.0016 mM, vs. 10 nM estradiol Homo sapiens 2,6-dichlorophenol
0.0022
-
 IC50: 0.0022 mM, vs. 10 nM estradiol Homo sapiens 2,5-dichlorophenol
0.0052
-
 IC50: 0.0052 mM, vs. 10 nM estradiol Homo sapiens 2-phenylphenol
0.013
-
 IC50: 0.013 mM, vs. 10 nM estradiol Homo sapiens 3,4-dichlorophenol
0.017
-
 IC50: 0.017 mM, vs. 10 nM estradiol Homo sapiens 3,5-dichlorophenol
0.02
-
 IC50: 0.02 mM, vs. 10 nM estradiol Homo sapiens 2-chlorophenol
0.024
-
 IC50: 0.024 mM, vs. 10 nM estradiol Homo sapiens 4-chloro-3-methylphenol
0.11
-
 IC50: 0.11 mM, vs. 10 nM estradiol Homo sapiens 4-Chlorophenol
0.13
-
 IC50: 0.13 mM, vs. 10 nM estradiol Homo sapiens 3-chlorophenol