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Literature summary for 2.8.2.15 extracted from

  • Chang, H.J.; Shi, R.; Rehse, P.; Lin, S.X.
    Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex (2004), J. Biol. Chem., 279, 2689-2696.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion technique, structure of human dehydroepiandrosterone adenosine sulfotransferase in complex with androsterone has been solved at 2.7 A resolution Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
androsterone stronger substrate inhibition than dehydroepiandrosterone adenosine Homo sapiens
dehydroepiandrosterone
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0021
-
androsterone pH 7.5, 37°C Homo sapiens
0.0031
-
dehydroepiandrosterone pH 7.5, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + androsterone Homo sapiens enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver adenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone Homo sapiens enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + androsterone
-
Homo sapiens adenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate
-
?
3'-phosphoadenylylsulfate + androsterone enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver Homo sapiens adenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
Homo sapiens adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver Homo sapiens adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
?

Synonyms

Synonyms Comment Organism
ADT sulfotransferase
-
Homo sapiens
dehydroepiandrosterone sulfotransferase
-
Homo sapiens
DHEA sulfotransferase
-
Homo sapiens
DHEA-ST
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.1
-
dehydroepiandrosterone pH 7.5, 37°C Homo sapiens
0.13
-
androsterone pH 7.5, 37°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0038
-
androsterone pH 7.5, 37°C Homo sapiens
0.0106
-
dehydroepiandrosterone pH 7.5, 37°C Homo sapiens