Literature summary for 2.8.2.15 extracted from

Cui, D.; Booth-Genthe, C.L.; Carlini, E.; Carr, B.; Schrag, M.L.
Heterotropic modulation of sulfotransferase 2A1 activity by celecoxib: product ratio switching of ethynylestradiol sulfation (2004), Drug Metab. Dispos., 32, 1260-1264.

Search for more literature for 2.8.2.15

Activating Compound

Activating Compound	Comment	Organism	Structure
celecoxib	heterotrophic modulator, switches sulfation from the 3-O-position to the 17beta-O-position and activates such that the total sulfated product exceed product formation by the native enzyme, 3fold to 4fold at 0.25 mM celecoxib	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
baculovirus expression-system, expression in Sf9 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
celecoxib	heterotrophic modulator, 3-O-sulfation is inhibited by celecoxib to the same extent, independent of the concentration of 17alpha-ethynylestradiol, switches sulfation from the 3-O-position to the 17beta-O-position	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.191	-	17alpha-ethynylestradiol	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylylsulfate + 17alpha-ethynylestradiol	celecoxib switches sulfation from the 3-O-position to the 17beta-O-position	Homo sapiens	adenosine 3',5'-bisphosphate + 17alpha-ethynylestradiol 3-sulfate	-	?

Synonyms

Synonyms	Comment	Organism
sulfotransferase 2A1	-	Homo sapiens
SULT2A1	-	Homo sapiens

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Release 2023.1 (January 2023)