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Literature summary for 2.8.2.15 extracted from

  • Ohkimoto, K.; Liu, M.Y.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
    Characterization of a zebrafish estrogen-sulfating cytosolic sulfotransferase: inhibitory effects and mechanism of action of phytoestrogens (2004), Chem. Biol. Interact., 147, 1-7.
    View publication on PubMed
Search for more literature for 2.8.2.15

Inhibitors

Inhibitors Comment Organism Structure
daidzein IC50: 0.008 mM, competitive Danio rerio
genistein IC50: 0.0025 mM, competitive Danio rerio
quercetin IC50: 0.0007 mM, competitive Danio rerio

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0036
-
 3,3',5-triiodothyronine
-
 Danio rerio
0.0046
-
 thyroxine
-
 Danio rerio
0.0125
-
 estrone
-
 Danio rerio
0.013
-
 17beta-estradiol
-
 Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Danio rerio 5829
-

Organism

Organism UniProt Comment Textmining
Danio rerio Q7ZUS4 recombinant enzyme
-

Purification (Commentary)

Purification (Comment) Organism
-
 Danio rerio

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0805
-
 reaction with estrone Danio rerio
0.0916
-
 reaction with 17beta-estradiol Danio rerio

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
 Danio rerio adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylylsulfate + 17beta-estradiol
-
 Danio rerio adenosine 3',5'-bisphosphate + estradiol-17beta 3-sulfate
-
 ?
3'-phosphoadenylylsulfate + 3,3',5-triidothyronine
-
 Danio rerio adenosine 3',5'-bisphosphate + 3,3',5-triiodothyronine 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + estrone
-
 Danio rerio adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylylsulfate + thyroxine
-
 Danio rerio adenosyl 3',5'-bisphosphate + O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodotyrosine
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0007
-
 IC50: 0.0007 mM, competitive Danio rerio quercetin
0.0025
-
 IC50: 0.0025 mM, competitive Danio rerio genistein
0.008
-
 IC50: 0.008 mM, competitive Danio rerio daidzein