Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estradiol | substrate inhibition above 0.002 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0013 | - |
estradiol | pH 7.6, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32500 | - |
1 * 32500 + 29500, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
rat | - |
Rattus norvegicus | - |
Sprague-Dawley | - |
Rattus norvegicus | - |
male rats | - |
Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00071 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + 17alpha-estradiol | estra-1,3,5(10)-triene-3,17alpha-diol | Rattus norvegicus | adenosine 3',5'-bisphosphate + ? | - |
r | |
3'-phosphoadenylylsulfate + 17alpha-estradiol | estra-1,3,5(10)-triene-3,17alpha-diol | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + ? | - |
r | |
3'-phosphoadenylylsulfate + 17beta-estradiol | estra-1,3,5(10)-triene-3,17alpha-diol | Rattus norvegicus | adenosine 3',5'-bisphosphate + ? | - |
r | |
3'-phosphoadenylylsulfate + 17beta-estradiol | estra-1,3,5(10)-triene-3,17alpha-diol | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + ? | - |
r | |
additional information | oestrone 3-sulfate is no substrate, no taurolithocholate sulfotransferase activity | Rattus norvegicus | ? | - |
? | |
additional information | oestrone 3-sulfate is no substrate, no taurolithocholate sulfotransferase activity | Rattus norvegicus Sprague-Dawley | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 32500 + 29500, SDS-PAGE | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
substrate estradiol | Rattus norvegicus |
5.5 | 6 | - |
Rattus norvegicus |
6 | - |
substrate estrone | Rattus norvegicus |
7 | 8 | biphasic pH optimum, activity for estradiol, but not estrone | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 9 | - |
Rattus norvegicus |