Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Homo sapiens |
expressed in HEK293 cells | Homo sapiens |
General Stability | Organism |
---|---|
SULT2A1 activity is consistently higher using NaH2PO4 buffer in a pH range from 5.5 to 6.5 | Homo sapiens |
SULT2A1 activity is consistently highest using NaH2PO4 buffer in a pH range from 5.5 to 6.5 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00186 | - |
taurine conjugated lithocholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.00192 | - |
glycine conjugated lithocholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.00202 | - |
lithocholic acid | apparent value, at pH 5.5 and 7.4, at 37°C | Homo sapiens | |
0.00202 | - |
lithocholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.00383 | - |
dehydroepiandrosterone | apparent value, at pH 5.5 and 7.4, at 37°C | Homo sapiens | |
0.00383 | - |
dehydroepiandrosterone | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.00886 | - |
deoxycholic acid | apparent value, at pH 5.5 and 7.4, at 37°C | Homo sapiens | |
0.00886 | - |
deoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.00993 | - |
taurine conjugated ursodeoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.01286 | - |
Ursodeoxycholic acid | apparent value, at pH 5.5 and 7.4, at 37°C | Homo sapiens | |
0.01286 | - |
ursodeoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.01566 | - |
chenodeoxycholic acid | apparent value, at pH 5.5 and 7.4, at 37°C | Homo sapiens | |
0.01566 | - |
chenodeoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.01836 | - |
taurine conjugated deoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.04509 | - |
taurine conjugated chenodeoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.04899 | - |
glycine conjugated chenodeoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.04957 | - |
glycine conjugated ursodeoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens | |
0.05459 | - |
glycine conjugated deoxycholate | apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | the addition of 2 mM MgCl2 to the reaction causes a 20% increase in sulfation activity, whereas higher concentrations of Mg2+ inhibit enzyme activity | Homo sapiens | |
Mg2+ | the presence of MgCl2 is not required for the SULT2A1 enzyme activity. However, the addition of 2 mM MgCl2 to the reaction causes a 20% increase in sulfation activity, whereas higher concentrations of Mg2+ inhibit SULT2A1 activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33780 | - |
x * 34000, SDS-PAGE, x * 33780, calculated from amino acid sequence | Homo sapiens |
34000 | - |
x * 34000, SDS-PAGE, x * 33780, calculated from amino acid sequence | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + chenodeoxycholic acid | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + cholic acid | Homo sapiens | lowest affinity to sulfation by SULT2A1 | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + deoxycholic acid | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + lithocholic acid | Homo sapiens | highest affinity to sulfation by SULT2A1 | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + ursodeoxycholic acid | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q06520 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl-sulfate + chenodeoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + deoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + glycine conjugated chenodeoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + glycine conjugated deoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + glycine conjugated lithocholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + glycine conjugated ursodeoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + lithocholate | highest affinity substrate | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + taurine conjugated chenodeoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + taurine conjugated deoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + taurine conjugated lithocholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + taurine conjugated ursodeoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl-sulfate + ursodeoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + chenodeoxycholic acid | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + cholic acid | lowest affinity to sulfation by SULT2A1 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + deoxycholic acid | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + lithocholic acid | highest affinity to sulfation by SULT2A1 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + ursodeoxycholic acid | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
additional information | no activity with cholate, glycine conjugated cholate and taurine conjugated cholate | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 34000, SDS-PAGE, x * 33780, calculated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
dehydroepiandrosterone-SULT | - |
Homo sapiens |
DHEA-SULT | - |
Homo sapiens |
hydroxysteroid sulfotransferase | - |
Homo sapiens |
sulfotransferase 2A1 | - |
Homo sapiens |
SULT2A1 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 9 | a more than 10fold increase in enzyme activity is observed with increasing the pH from 4.0 to 5.5, while further increase in pH in 10 mM Tris-HCl buffer is associated with a decline in the enzyme activity | Homo sapiens |
4 | 9 | more than a 10fold increase in SULT2A1 activity is observed with increasing the pH from 4.0 to 5.5, while a further increase in pH in 10 mM Tris-HCl buffer (up to pH 9-0) is associated with a 50% decline in the optimum enzyme activity | Homo sapiens |