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Literature summary for 2.8.2.14 extracted from
- Purification and characterization of bile salt sulfotransferase from human liver (1985), Arch. Biochem. Biophys., 241, 371-379.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-ketolithocholate | - |
Homo sapiens |  |
| adenosine-3',5'-diphosphate | - |
Homo sapiens | |
| glycolithocholate | - |
Homo sapiens | |
| p-chloromercuribenzoate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0007 | - |
3'-phosphoadenylylsulfate | pH 6.5, 37°C | Homo sapiens | |
| 0.002 | - |
glycolithocholate | pH 6.5, 37°C | Homo sapiens | |
| 0.0024 | - |
5-cholenic acid-3beta-ol | pH 6.5, 37°C | Homo sapiens | |
| 0.0025 | - |
lithocholate | pH 6.5, 37°C | Homo sapiens | |
| 0.025 | - |
3alpha-7alpha-chenodeoxycholic acid | pH 6.5, 37°C | Homo sapiens | |
| 0.071 | - |
3alpha,7alpha,12alpha-cholic acid | pH 6.5, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
gel filtration | Homo sapiens |
| 67000 | - |
gel filtration | Homo sapiens |
| 68000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.018 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 3alpha-7alpha-chenodeoxycholic acid | - |
Homo sapiens | ? | - |
? | |
| 3'-phosphoadenylyl-sulfate + 3alpha,7alpha,12alpha-cholic acid | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 3alpha,7alpha,12alpha-cholic acid sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + 5-cholenic acid-3beta-ol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 5-cholenic acid-3-beta-ol sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + cholic acid | - |
Homo sapiens | adenosine 3',5'-bisphosphate + cholic acid sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycochenodeoxycholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Homo sapiens | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| additional information | purified enzyme displays no activity toward estrone, testosterone, or phenol | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BSS | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 10.5 | 50% maximum activity at pH 5.8 and pH 7.5 | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
adenosine-3',5'-diphosphate | pH 6.5, 37°C | Homo sapiens | |
| 0.0006 | - |
3-ketolithocholate | pH 6.5, 37°C | Homo sapiens | |
| 0.0022 | - |
glycolithocholate | pH 6.5, 37°C | Homo sapiens | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | isoelectric focusing electrophoresis | - |
5.2 |
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