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Literature summary for 2.8.2.14 extracted from

  • Chen, L.J.
    Bile salt sulfotransferase in guinea pig liver (1982), Biochim. Biophys. Acta, 717, 316-321.
    View publication on PubMed

General Stability

General Stability Organism
freezing and thawing results in significant loss in activity, substantial stabilization with addition of sucrose Cavia porcellus

Inhibitors

Inhibitors Comment Organism Structure
7,12-diketochenodeoxycholate
-
Cavia porcellus
adenosine-3',5'-diphosphate
-
Cavia porcellus
ATP
-
Cavia porcellus
EDTA
-
Cavia porcellus
iodoacetate
-
Cavia porcellus
NaF
-
Cavia porcellus
NaN3
-
Cavia porcellus
p-chloromercuribenzoate
-
Cavia porcellus
Taurodehydrocholate
-
Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0014
-
3'-phosphoadenylylsulfate pH 6.5, 37°C Cavia porcellus
0.077
-
taurolithocholate pH 6.5, 37°C Cavia porcellus

Metals/Ions

Metals/Ions Comment Organism Structure
CaCl2 activity 107% Cavia porcellus
CuCl2 activity 136% Cavia porcellus
CuSO4 activity 107% Cavia porcellus
FeSO4 activity 134% Cavia porcellus
KCl activity 128% Cavia porcellus
LiCl activity 108% Cavia porcellus
Mg2+ required for activity Cavia porcellus
ZnSO4 activity 111% Cavia porcellus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000
-
gel filtration Cavia porcellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + taurolithocholate Cavia porcellus
-
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
guinea pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Cavia porcellus
-
additional information no activity in kidney Cavia porcellus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0216
-
-
Cavia porcellus

Storage Stability

Storage Stability Organism
-20°C, (NH4)2SO4 precipitate, stable for several months Cavia porcellus
4°C, loses about 50% activity in 1 week Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + isolithocholic acid 5beta-cholanoic acid-3beta-ol Cavia porcellus adenosine 3',5'-bisphosphate + isolithocholate sulfate
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
-
Cavia porcellus adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
?
3'-phosphoadenylyl-sulfate + 5-cholenic acid-3beta-ol
-
Cavia porcellus adenosine 3',5'-bisphosphate + 5-cholenic acid-3-beta-ol sulfate
-
?
3'-phosphoadenylyl-sulfate + 5alpha-cholanoic acid-3beta-ol
-
Cavia porcellus adenosine 3',5'-bisphosphate + 5alpha-cholanic acid-3beta-ol sulfate
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
-
Cavia porcellus adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
?
3'-phosphoadenylyl-sulfate + glycocholate
-
Cavia porcellus adenosine 3',5'-bisphosphate + glycocholate 3-sulfate
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
-
Cavia porcellus adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
?
3'-phosphoadenylyl-sulfate + lithocholate
-
Cavia porcellus adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
-
Cavia porcellus adenosine 3',5'-bisphosphate + taurochenodeoxycholate monosulfate + taurochenodeoxycholate disulfate
-
?
3'-phosphoadenylyl-sulfate + taurocholate
-
Cavia porcellus adenosine 3',5'-bisphosphate + taurocholate monosulfate + taurocholate disulfate + taurocholate trisulfate
-
?
additional information purified enzyme does not react with estrone, estradiol, testosterone, dehydroepiandrosterone, cholesterol, phenol, tyramine, and serotonin Cavia porcellus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
Cavia porcellus

pI Value

Organism Comment pI Value Maximum pI Value
Cavia porcellus
-
5.9 5.6