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Literature summary for 2.8.2.1 extracted from
- Pharmacogenetics of human cytosolic sulfotransferases (2006), Oncogene, 25, 1673-1678.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| SULT1A1, DNA and amino acid sequence determination and analysis, genotyping, determination and sequence analysis of putative transcription factor binding sites, SULT1A1 promoter haplotype frequencies in African-American, Caucasian, and Chinese individuals, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 2-methoxyestradiol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? |  |
| 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen | Homo sapiens | a potent inducer of apoptosis in breast tumor cell lines | adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen | - |
? | |
| 3'-phosphoadenylyl sulfate + 4-nitrophenol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + acetaminophen | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + minoxidil | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
| additional information | Homo sapiens | SULT1A1 sulfates a wide variety of phenolic xenobiotics, as well as iodothyronines, and also certain N-hydroxy heterocyclic and aromatic amines, SULT1A1 is a detoxifying enzyme, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P50225 | SULT1A1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | expression of SULT1A1, activity varies with gender and season, platelet phenotypes, overview | Homo sapiens | - |
| liver | high expression level of SULT1A1 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 2-methoxyestradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen | - |
? | |
| 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen | a potent inducer of apoptosis in breast tumor cell lines | Homo sapiens | adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen | - |
? | |
| 3'-phosphoadenylyl sulfate + 4-nitrophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + acetaminophen | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + minoxidil | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| additional information | SULT1A1 sulfates a wide variety of phenolic xenobiotics, as well as iodothyronines, and also certain N-hydroxy heterocyclic and aromatic amines, SULT1A1 is a detoxifying enzyme, overview | Homo sapiens | ? | - |
? | |
| additional information | SULT1A1 catalyzes the sulfation of the active metabolizes of tamoxifen and endoxifen | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT1A1 | - |
Homo sapiens |
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