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Literature summary for 2.8.2.1 extracted from
- Effect of resveratrol on 17{beta}-estradiol sulfation by human hepatic and jejunal S9 and recombinant SULT1E1 (2008), Drug Metab. Dispos., 36, 129-136.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R213H | polymorphism of SULT1A1, overview | Homo sapiens |
| R213H | polymorphism of SULT1A1, the mutant variant is termed SULT1A1*2 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + estradiol | Homo sapiens | the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity | adenosine 3',5'-bisphosphate + estradiol sulfate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
female and male | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | recombinant SULT1A1 expressed in insect Sf9 cells | Homo sapiens | - |
| intestine | - |
Homo sapiens | - |
| jejunum | S9 fractions | Homo sapiens | - |
| liver | S9 fractions | Homo sapiens | - |
| additional information | analysis of tissue specific expression of the enzyme, overview | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0000000009 | - |
reaction of EC 2.8.2.4, estrone sulfotransferase, SULT1A2 | Homo sapiens |
| 0.0000000023 | - |
reaction of EC 2.8.2.4, estrone sulfotransferase, SULT1A1*2 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + estradiol | the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity | Homo sapiens | adenosine 3',5'-bisphosphate + estradiol sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT1A1 | - |
Homo sapiens |
| SULT1A1*2 | - |
Homo sapiens |
| SULT1A2 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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