Cloned (Comment) | Organism |
---|---|
expression of SULT1A1 in TB1 cells as maltose-binding-protein fusion protein | Homo sapiens |
expression of SULT1B1 in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3',4,6-tetrachlorobiphenyl-4'-ol | i.e. 4'-OH-CB69; i.e. 4'-OH-CB69 | Homo sapiens | |
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol | i.e. 4'-OH-CB165, a mixed, noncompetitive-uncompetitive inhibitor; i.e. 4'-OH-CB165, a mixed, noncompetitive-uncompetitive inhibitor | Homo sapiens | |
2,3,3',5,6-pentachlorobiphenyl-4'-ol | i.e. 4'-OH-CB112; i.e. 4'-OH-CB112 | Homo sapiens | |
3',4,5'-trichlorobiphenyl-4'-ol | i.e. 4'-OH-CB39; i.e. 4'-OH-CB39 | Homo sapiens | |
3,3',4-trichlorobiphenyl-6'-ol | i.e. 6'-OH-CB35; i.e. 6'-OH-CB35 | Homo sapiens | |
3,3',5',6-tetrachlorobiphenyl-4'-ol | i.e. 4'-OH-CB72; i.e. 4'-OH-CB72 | Homo sapiens | |
4-chlorobiphenyl-3'-ol | i.e. 3'-OH-CB3, inhibitory effects on different SULT1A1 genotypes, overview; i.e. 3'-OH-CB3, inhibitory effects on different SULT1A1 genotypes, overview | Homo sapiens | |
4-chlorobiphenyl-4'-ol | i.e. 4'-OH-CB3; i.e. 4'-OH-CB3 | Homo sapiens | |
additional information | inhibitory potency of diverse derivatives of hydroxylated polychlorobiphenyls, no inhibition by 3,3',4,5,6-pentachlorobiphenyl-4'-ol, 3,3',4,5'-tetrachlorobiphenyl-4'-ol, 3,3',5-trichlorobiphenyl-4'-ol, 3,3',4-trichlorobiphenyl-4'-ol, 2,3',5'-trichlorobiphenyl-4'-ol, 3',5'-dichlorobiphenyl-4'-ol, 4-chlorobiphenyl-2'-ol, overview; inhibitory potency of diverse derivatives of hydroxylated polychlorobiphenyls, no inhibition by 3,3',4,5,6-pentachlorobiphenyl-4'-ol, 3,3',4,5'-tetrachlorobiphenyl-4'-ol, 3,3',5-trichlorobiphenyl-4'-ol, 3,3',4-trichlorobiphenyl-4'-ol, 2,3',5'-trichlorobiphenyl-4'-ol, 3',5'-dichlorobiphenyl-4'-ol, 4-chlorobiphenyl-2'-ol, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00119 | - |
4-nitrophenol | pH 7.0, 37°C, SULT1A1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 4-nitrophenol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43704 | - |
- |
Homo sapiens | P50225 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | SULT1A1 is the predominant phenol sulfotransferase in liver | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 2,3,3',5,5',6-hexachlorobiphenyl-4'-yl | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 2,2',3,3',5,5'-hexachlorobiphenyl-4'-yl sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 2,3,5,5',6-pentachlorobiphenyl-4'-yl | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 2,2',3,3',5'-pentachlorobiphenyl-4'-yl sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 3',4',5-trichlorobiphenyl-2-yl | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 3',4',5-trichlorobiphenyl-2-yl sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-3'-ol | low activity | Homo sapiens | adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-3-yl sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-4'-ol | low activity | Homo sapiens | adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-4-yl sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 4-nitrophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phenol sulfotransferase 1A1 | - |
Homo sapiens |
SULT1A1 | - |
Homo sapiens |
SULT1B1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics with hydroxylated polychlorobiphenyls | Homo sapiens | |
0.0018 | - |
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol | pH 7.0, 37°C, SULT1A1 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00026 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 4-chlorobiphenyl-3'-ol | |
0.00041 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 3,3',5',6-tetrachlorobiphenyl-4'-ol | |
0.00051 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 2,3,3',5,5',6-hexachlorobiphenyl-4'-ol | |
0.00054 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 2,3,3',5,6-pentachlorobiphenyl-4'-ol | |
0.00101 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 2,3',4,6-tetrachlorobiphenyl-4'-ol | |
0.00196 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 3',4,5'-trichlorobiphenyl-4'-ol | |
0.0062 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 4-chlorobiphenyl-4'-ol | |
0.0082 | - |
pH 7.0, 37°C, SULT1B1 | Homo sapiens | 4-chlorobiphenyl-3'-ol | |
0.0117 | - |
pH 7.0, 37°C, SULT1B1 | Homo sapiens | 3,3',4-trichlorobiphenyl-6'-ol | |
0.0351 | - |
pH 7.0, 37°C, SULT1A1 | Homo sapiens | 3,3',4-trichlorobiphenyl-6'-ol | |
0.1 | - |
above, pH 7.0, 37°C, SULT1B1 | Homo sapiens | 4-chlorobiphenyl-4'-ol | |
0.1 | - |
above, pH 7.0, 37°C, SULT1B1 | Homo sapiens | 2,3,3',5,5',6-hexachlorobiphenyl-4'-ol | |
0.1 | - |
above, pH 7.0, 37°C, SULT1B1 | Homo sapiens | 2,3,3',5,6-pentachlorobiphenyl-4'-ol | |
0.1 | - |
above, pH 7.0, 37°C, SULT1B1 | Homo sapiens | 3,3',5',6-tetrachlorobiphenyl-4'-ol | |
0.1 | - |
above, pH 7.0, 37°C, SULT1B1 | Homo sapiens | 2,3',4,6-tetrachlorobiphenyl-4'-ol | |
0.1 | - |
above, pH 7.0, 37°C, SULT1B1 | Homo sapiens | 3',4,5'-trichlorobiphenyl-4'-ol |