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Literature summary for 2.8.2.1 extracted from
- Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3 (2007), Biopharm. Drug Dispos., 28, 491-500.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3 | Homo sapiens |
| expression of His-tagged SULT1A1 in Escherichia coli | Homo sapiens |
| expression of His-tagged SULT1A3 in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (+)-catechin | - |
Homo sapiens |  |
| (-)-epicatechin | complete inhibition of SULT1A1 | Homo sapiens | |
| (-)-epicatechin gallate | almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3 | Homo sapiens | |
| (-)-epigallocatechin | complete inhibition of SULT1A1 | Homo sapiens | |
| (-)-epigallocatechin gallate | almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3 | Homo sapiens | |
| 6',7'-dihydroxybergamottin | inhibition of SULT1A1; significantly inhibits the activity of SULT1A1 | Homo sapiens | |
| bergamottin | inhibition of SULT1A1; inhibition of SULT1A3; significantly inhibits the activity of SULT1A1 | Homo sapiens | |
| additional information | grapefruit juice and orange juice show a weak inhibition of SULT1A3, green tea, black tea and oolong tea show a good inhibition of SULT1A3; naringin and bergamottin do not inhibit SULT1A1, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview; naringin does not inhibit SULT1A1, grapefruit juice and orange juice show a good inhibition of SULT1A1, green tea, black tea and oolong tea are also inhibitors of SULT1A1; no inhibition of SULT1A3 by 60,70-dihydroxybergamottin, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview | Homo sapiens | |
| naringenin | inhibition of SULT1A1; partial inhibition of SULT1A3; significantly inhibits the activity of SULT1A1 | Homo sapiens | |
| naringin | inhibition of SULT1A3 | Homo sapiens | |
| nobiletin | belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3 | Homo sapiens | |
| quercetin | belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3 | Homo sapiens | |
| tangeretin | belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3 | Homo sapiens | |
| theaflavin | complete inhibition of SULT1A1; strong inhibition of SULT1A3 | Homo sapiens | |
| thearubigin | complete inhibition of SULT1A1; strong inhibition of SULT1A3 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + a phenol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
| additional information | Homo sapiens | SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver | ? | - |
? | |
| additional information | Homo sapiens | SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P0DMM9 | - |
- |
| Homo sapiens | P0DMM9 | SULT1A3; SULT1A3 | - |
| Homo sapiens | P50225 | - |
- |
| Homo sapiens | P50225 | SULT1A1; SULT1A1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| one-step column chromatography, His-binding metal chelation resin column | Homo sapiens |
| recombinant His-tagged SULT1A1 from Escherichia coli by nickel affinity chromatography | Homo sapiens |
| recombinant His-tagged SULT1A3 from Escherichia coli by nickel affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | SULT1A3 | Homo sapiens | - |
| liver | SULT1A1 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 4-nitrophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + a phenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + dopamine | as dopamine hydrochloride | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + dopamine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dopamine sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + fenoterol | as fenoterol hydrobromide | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + isoproterenol | as isoproterenol hydrochloride | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + isoproterenol | as isoproterenol hydrochloride | Homo sapiens | adenosine 3',5'-bisphosphate + isoproterenol sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + p-nitrophenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + ritodrine | as ritodrine hydrochloride | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + salbutamol | as salbutamol hemisulfate | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + terbutaline | as terbutaline hemisulfate | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| additional information | SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver | Homo sapiens | ? | - |
? | |
| additional information | SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT1A1 | - |
Homo sapiens |
| SULT1A3 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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