BRENDA - Enzyme Database
show all sequences of 2.8.2.1

Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3

Nishimuta, H.; Ohtani, H.; Tsujimoto, M.; Ogura, K.; Hiratsuka, A.; Sawada, Y.; Biopharm. Drug Dispos. 28, 491-500 (2007)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged SULT1A1 in Escherichia coli; expression of His-tagged SULT1A3 in Escherichia coli
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
(+)-catechin
;
Homo sapiens
(-)-epicatechin
; complete inhibition of SULT1A1
Homo sapiens
(-)-epicatechin gallate
almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3
Homo sapiens
(-)-epigallocatechin
; complete inhibition of SULT1A1
Homo sapiens
(-)-epigallocatechin gallate
almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3
Homo sapiens
6',7'-dihydroxybergamottin
; inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
bergamottin
; inhibition of SULT1A1; inhibition of SULT1A3; significantly inhibits the activity of SULT1A1
Homo sapiens
additional information
grapefruit juice and orange juice show a weak inhibition of SULT1A3, green tea, black tea and oolong tea show a good inhibition of SULT1A3; naringin and bergamottin do not inhibit SULT1A1, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview; naringin does not inhibit SULT1A1, grapefruit juice and orange juice show a good inhibition of SULT1A1, green tea, black tea and oolong tea are also inhibitors of SULT1A1; no inhibition of SULT1A3 by 60,70-dihydroxybergamottin, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview
Homo sapiens
naringenin
; inhibition of SULT1A1; partial inhibition of SULT1A3; significantly inhibits the activity of SULT1A1
Homo sapiens
naringin
inhibition of SULT1A3
Homo sapiens
nobiletin
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
Homo sapiens
quercetin
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
Homo sapiens
tangeretin
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
Homo sapiens
theaflavin
complete inhibition of SULT1A1; strong inhibition of SULT1A3
Homo sapiens
thearubigin
complete inhibition of SULT1A1; strong inhibition of SULT1A3
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
;
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3'-phosphoadenylyl sulfate + a phenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
?
additional information
Homo sapiens
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
?
-
-
-
additional information
Homo sapiens
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P0DMM9
; SULT1A3; SULT1A3
-
Homo sapiens
P50225
; SULT1A1; SULT1A1
-
Purification (Commentary)
Commentary
Organism
one-step column chromatography, His-binding metal chelation resin column; one-step column chromatography, His-binding metal chelation resin column; recombinant His-tagged SULT1A1 from Escherichia coli by nickel affinity chromatography; recombinant His-tagged SULT1A3 from Escherichia coli by nickel affinity chromatography
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
intestine
SULT1A3
Homo sapiens
-
liver
SULT1A1
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
as dopamine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + fenoterol
as fenoterol hydrobromide
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + isoproterenol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + p-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + ritodrine
as ritodrine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + salbutamol
as salbutamol hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + terbutaline
as terbutaline hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
additional information
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
672630
Homo sapiens
?
-
-
-
-
additional information
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
672630
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at; assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
assay at; assay at
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged SULT1A1 in Escherichia coli
Homo sapiens
expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged SULT1A3 in Escherichia coli
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(+)-catechin
-
Homo sapiens
(-)-epicatechin
complete inhibition of SULT1A1
Homo sapiens
(-)-epicatechin
-
Homo sapiens
(-)-epicatechin gallate
almost complete inhibition of SULT1A1
Homo sapiens
(-)-epicatechin gallate
almost complete inhibition of SULT1A3
Homo sapiens
(-)-epigallocatechin
complete inhibition of SULT1A1
Homo sapiens
(-)-epigallocatechin
-
Homo sapiens
(-)-epigallocatechin gallate
almost complete inhibition of SULT1A1
Homo sapiens
(-)-epigallocatechin gallate
almost complete inhibition of SULT1A3
Homo sapiens
6',7'-dihydroxybergamottin
inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
6',7'-dihydroxybergamottin
-
Homo sapiens
bergamottin
inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
bergamottin
; inhibition of SULT1A3
Homo sapiens
additional information
naringin and bergamottin do not inhibit SULT1A1, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview; naringin does not inhibit SULT1A1, grapefruit juice and orange juice show a good inhibition of SULT1A1, green tea, black tea and oolong tea are also inhibitors of SULT1A1
Homo sapiens
additional information
grapefruit juice and orange juice show a weak inhibition of SULT1A3, green tea, black tea and oolong tea show a good inhibition of SULT1A3; no inhibition of SULT1A3 by 60,70-dihydroxybergamottin, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview
Homo sapiens
naringenin
inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
naringenin
; partial inhibition of SULT1A3
Homo sapiens
naringin
inhibition of SULT1A3
Homo sapiens
nobiletin
belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1
Homo sapiens
nobiletin
belongs to the most potent inhibitors; partial inhibition of SULT1A3
Homo sapiens
quercetin
belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1
Homo sapiens
quercetin
belongs to the most potent inhibitors; partial inhibition of SULT1A3
Homo sapiens
tangeretin
belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1
Homo sapiens
tangeretin
belongs to the most potent inhibitors; partial inhibition of SULT1A3
Homo sapiens
theaflavin
; complete inhibition of SULT1A1
Homo sapiens
theaflavin
; strong inhibition of SULT1A3
Homo sapiens
thearubigin
; complete inhibition of SULT1A1
Homo sapiens
thearubigin
; strong inhibition of SULT1A3
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3'-phosphoadenylyl sulfate + a phenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
?
additional information
Homo sapiens
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
?
-
-
-
additional information
Homo sapiens
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
one-step column chromatography, His-binding metal chelation resin column; recombinant His-tagged SULT1A1 from Escherichia coli by nickel affinity chromatography
Homo sapiens
one-step column chromatography, His-binding metal chelation resin column; recombinant His-tagged SULT1A3 from Escherichia coli by nickel affinity chromatography
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
intestine
SULT1A3
Homo sapiens
-
liver
SULT1A1
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
as dopamine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + fenoterol
as fenoterol hydrobromide
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + isoproterenol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + p-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + ritodrine
as ritodrine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + salbutamol
as salbutamol hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + terbutaline
as terbutaline hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
additional information
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
672630
Homo sapiens
?
-
-
-
-
additional information
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
672630
Homo sapiens
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
assay at
Homo sapiens
Other publictions for EC 2.8.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737725
Wang
Isozyme specific allosteric re ...
Homo sapiens
Biochemistry
55
4036-4046
2016
-
-
-
-
-
-
1
-
1
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
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-
1
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1
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-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738482
Zhang
Sulfation of benzyl alcohol by ...
Homo sapiens
J. Appl. Toxicol.
36
1090-1094
2016
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
1
-
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-
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-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737405
Hartog
-
Substrate engineering and its ...
Desulfitobacterium hafniense
Adv. Synth. Catal.
357
2629-2632
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
5
-
-
-
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1
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5
-
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-
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-
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738064
Purchartova
-
Prokaryotic and eukaryotic ary ...
Desulfitobacterium hafniense, Rattus norvegicus
ChemCatChem
7
3152-3162
2015
-
-
2
-
-
-
-
-
-
-
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2
-
2
-
-
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1
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9
-
2
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2
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2
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2
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1
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9
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
738167
Van Der Horst
-
Enzymatic sulfation of phenoli ...
Desulfitobacterium hafniense
Eur. J. Org. Chem.
2015
534-541
2015
-
-
1
-
-
-
-
-
-
-
-
1
-
1
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-
1
-
-
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-
8
-
-
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-
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-
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-
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1
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1
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1
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8
-
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-
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-
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-
737690
Malojcic
Structural and mechanistic ins ...
Escherichia coli, Escherichia coli CFT073
Biochemistry
53
1870-1877
2014
-
-
-
1
-
-
-
-
-
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2
-
5
-
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2
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1
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2
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2
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
737962
Ro
-
In vitro metabolic modulation ...
Rattus norvegicus
Bull. Korean Chem. Soc.
35
2577-2580
2014
-
-
-
-
-
-
8
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
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-
-
-
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-
-
-
-
-
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8
-
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1
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-
-
-
-
-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738063
Ayuso-Fernandez
-
Aryl sulfotransferase from Hal ...
Haliangium ochraceum
ChemCatChem
6
1059-1065
2014
-
-
1
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
1
3
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
1
-
-
-
1
3
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
724077
Purchartova
Enzymatic preparation of silyb ...
Rattus norvegicus
Appl. Microbiol. Biotechnol.
97
10391-10398
2013
1
-
1
-
-
-
-
-
1
-
1
1
1
3
-
-
1
-
-
2
-
3
4
1
-
-
-
-
-
-
-
-
-
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-
1
-
1
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-
-
-
-
-
-
1
-
1
1
1
-
-
1
-
2
-
3
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724828
Rohn
Potent inhibition of human sul ...
Homo sapiens
Drug Metab. Dispos.
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2012
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Oxidative modification of rat ...
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726285
Berger
The molecular basis for the br ...
Homo sapiens
PLoS ONE
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3
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1
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Clioquinol is sulfated by huma ...
Homo sapiens
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4
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706669
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The loss of phenol sulfotransf ...
Homo sapiens
Proteomics
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1
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723935
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Spectrofluorometric assay for ...
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1
1
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4
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1
1
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1
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Functional genetic variants in ...
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3
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Teramoto
Structural basis for the broad ...
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4
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702054
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Snapshot of a Michaelis comple ...
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1
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Inhibitory effects of kynureni ...
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673308
Furimsky
Effect of resveratrol on 17{be ...
Homo sapiens
Drug Metab. Dispos.
36
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2008
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1
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2
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1
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1
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1
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5
2
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1
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1
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691593
Murias
Metabolism of resveratrol in b ...
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Cancer Lett.
261
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1
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1
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2
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-
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702738
Hattori
Cloning, expression, and chara ...
Drosophila melanogaster
Biosci. Biotechnol. Biochem.
72
540-547
2008
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1
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7
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2
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6
1
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1
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1
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6
1
1
5
7
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1
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7
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2
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6
1
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1
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-
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703487
James
Effects of food natural produc ...
Homo sapiens
Environ. Toxicol. Pharmacol.
25
211-217
2008
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2
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1
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1
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1
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1
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2
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2
2
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1
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1
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1
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1
-
-
-
-
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-
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1
1
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705075
Saruwatari
Pomegranate juice inhibits sul ...
Homo sapiens
J. Med. Food
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2008
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1
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1
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1
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1
1
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1
-
-
1
-
-
-
-
-
-
-
-
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1
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1
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671616
Chodavarapu
Reversible covalent inhibition ...
Bos taurus
Arch. Biochem. Biophys.
457
197-204
2007
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1
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-
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4
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1
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2
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1
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-
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3
1
1
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-
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1
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4
-
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-
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1
-
-
-
-
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4
4
-
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-
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1
-
-
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1
-
-
-
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3
1
1
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-
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1
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671885
Yasuda
Generation and release of nitr ...
Homo sapiens
Biochem. J.
401
497-503
2007
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5
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6
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1
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2
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1
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-
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7
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1
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-
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3
5
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6
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1
-
-
-
2
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-
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-
-
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671926
Riches
Comparison of 2-aminophenol an ...
Homo sapiens
Biochem. Pharmacol.
74
352-358
2007
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1
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6
1
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3
2
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6
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1
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-
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1
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2
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-
-
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2
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-
-
-
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2
2
6
3
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-
-
-
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-
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4
4
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6
-
3
-
-
-
3
-
-
-
-
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-
-
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671928
Itaeaho
Regioselective sulfonation of ...
Homo sapiens
Biochem. Pharmacol.
74
504-510
2007
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1
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-
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2
3
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1
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2
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1
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1
1
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2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
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2
-
3
-
-
-
1
-
-
-
1
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
672462
Najmanovich
Analysis of binding site simil ...
Homo sapiens
Bioinformatics
23
e104-e109
2007
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-
-
-
-
-
-
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2
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1
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2
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-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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2
-
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1
-
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-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
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672630
Nishimuta
Inhibitory effects of various ...
Homo sapiens
Biopharm. Drug Dispos.
28
491-500
2007
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1
-
-
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15
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1
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4
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5
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1
-
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2
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22
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1
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1
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2
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29
-
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2
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4
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2
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2
-
-
22
-
2
-
-
-
2
-
-
-
-
-
-
-
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673307
Ung
Variable sulfation of dietary ...
Homo sapiens
Drug Metab. Dispos.
35
740-746
2007
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1
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-
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12
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2
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1
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6
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1
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1
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-
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-
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1
-
-
-
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-
-
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12
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-
-
-
-
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-
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1
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6
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1
-
-
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1
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-
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-
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674034
Hempel
Human cytosolic sulfotransfera ...
Homo sapiens
Int. J. Biochem. Cell Biol.
39
685-689
2007
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1
1
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-
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2
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1
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2
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-
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-
-
-
-
-
-
-
-
-
-
-
-
1
1
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-
-
-
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2
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1
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1
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2
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-
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675515
Yasuda
Hydroxylated serotonin and dop ...
Homo sapiens
J. Neurochem.
103
2679-2689
2007
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1
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8
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1
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3
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1
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2
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5
2
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5
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2
1
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8
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1
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3
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675751
Bian
Induction of human sulfotransf ...
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Life Sci.
81
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2007
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1
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3
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1
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-
-
1
-
-
-
-
-
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1
-
1
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-
-
-
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1
-
-
-
-
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3
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-
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1
-
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3
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1
-
-
-
1
-
-
-
-
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676745
Allali-Hassani
-
Structural and chemical profil ...
Homo sapiens
PLoS Biol.
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1063-1078
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1
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1
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1
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3
1
1
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1
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-
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1
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6
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1
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1
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1
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3
1
1
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-
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1
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-
-
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677196
Yasuda
Cigarette smoke toxicants as s ...
Homo sapiens
Toxicol. Appl. Pharmacol.
221
13-20
2007
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3
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7
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4
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53
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1
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1
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-
-
-
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-
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3
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6
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27
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21
17
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53
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6
-
-
-
6
-
-
-
-
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-
-
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677219
Prusakiewicz
Parabens inhibit human skin es ...
Homo sapiens
Toxicology
232
248-256
2007
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1
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-
-
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-
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-
-
-
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1
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1
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-
-
-
-
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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671573
Martin-Skilton
Sulfotransferase activities to ...
Lepidorhombus boscii, Mullus barbatus
Aquat. Toxicol.
79
24-30
2006
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-
-
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6
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3
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8
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-
-
-
-
-
-
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-
-
-
-
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6
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-
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5
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-
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3
-
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8
-
-
-
-
-
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-
-
-
-
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-
-
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671776
Assem
Substrate characterisation of ...
Squalius cephalus
Biochem. Biophys. Res. Commun.
349
900-905
2006
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1
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6
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7
2
1
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1
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1
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-
-
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2
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1
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6
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7
2
1
-
-
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1
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672845
Stakhiv
Phase II antioxidant enzyme ac ...
Rattus norvegicus
Brain Res.
1104
80-91
2006
1
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1
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7
2
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1
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-
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-
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-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
7
2
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1
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672912
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2
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2
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1
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-
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1
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1
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1
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3
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1
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-
2
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2
-
1
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1
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673032
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Polychlorobiphenylols are sele ...
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Chem. Biol. Interact.
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12
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1
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1
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-
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2
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16
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-
2
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-
-
-
16
18
3
1
2
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-
2
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-
-
-
-
2
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-
12
-
2
-
-
-
2
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-
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673189
King
Inhibition of human phenol and ...
Homo sapiens
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1
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10
1
1
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1
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3
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-
1
-
1
1
-
1
-
-
-
1
-
-
-
6
-
9
-
-
1
-
-
-
-
9
10
6
1
1
-
-
1
-
-
-
-
-
1
-
1
1
-
1
-
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-
1
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673454
Ohtake
Frequency distribution of phen ...
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1
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-
1
1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
1
-
1
-
1
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674044
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Human sulphotransferases are i ...
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Int. J. Cancer
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2
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-
-
-
1
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-
-
-
-
1
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-
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-
1
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-
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-
-
2
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-
2
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-
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676095
Nagar
Sulfotransferase (SULT) 1A1 po ...
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1
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1
1
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1
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6
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1
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1
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1
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1
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1
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2
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1
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6
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1
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1
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676256
Nowell
Pharmacogenetics of human cyto ...
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1
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Wang
Sulfation of tibolone metaboli ...
Homo sapiens
Steroids
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8
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2
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6
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8
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1
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2
6
1
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11
1
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1
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Lu
Crystal structure of human sul ...
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Yeh
Induction of phenolsulfotransf ...
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2
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Amino acid residue 247 in cani ...
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6
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Characterization of the rates ...
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661580
Nakano
Regioselective monosulfation a ...
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22
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17
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22
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661915
Yeh
Synergistic effect of antioxid ...
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1
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1
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1
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Barnett
Active site mutations and subs ...
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4
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Novakova
Study of enzyme kinetics of ph ...
Homo sapiens
J. Chromatogr. A
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2004
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2
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1
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1
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1
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662515
Ebmeier
Human thyroid phenol sulfotran ...
Homo sapiens
J. Clin. Endocrinol. Metab.
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2004
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4
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4
4
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2
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662758
Lin
Molecular cloning and function ...
Sus scrofa
Mamm. Genome
15
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663431
Davies
Effects of culture with TNF-al ...
Homo sapiens
Toxicol. In Vitro
18
749-754
2004
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Tabrett
Phenol sulfotransferase 1A1 ac ...
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2003
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2
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Chen
Arginine residues in the activ ...
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Yeh
Effects of phenolic acids on h ...
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645682
Tsoi
Canine sulfotransferase SULT1A ...
Canis lupus familiaris
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Riley
Isolation and characterisation ...
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Pai
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8
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645678
Dubin
Thermostable (SULT1A1) and the ...
Homo sapiens
Bone
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617-624
2001
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2
4
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1
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5
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645679
Li
Characterization of human live ...
Homo sapiens
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1
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8
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8
-
1
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2
-
1
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-
645680
Honma
Enzymatic characterization and ...
Homo sapiens, Mus musculus, Mus musculus BALB/c, Mus musculus ST1a4, Oryctolagus cuniculus, Oryctolagus cuniculus ST1A8, Rattus norvegicus
Drug Metab. Dispos.
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2001
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16
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70
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127
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4
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4
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4
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1
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16
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1
4
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127
-
4
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4
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-
645688
Duffel
Enzymatic aspects of the pheno ...
Bos taurus, Canis lupus familiaris, Homo sapiens, Macaca fascicularis, Macaca fascicularis ST1A9, Mus musculus, Mus musculus ST1a4, Mus musculus ST1c4, Oryctolagus cuniculus, Oryctolagus cuniculus ST1A8, Oryctolagus cuniculus ST1C5, Rattus norvegicus
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2
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1
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162
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2
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2
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7
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18
3
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3
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1
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5
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162
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2
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645672
Marshall
Redox control of aryl sulfotra ...
Rattus norvegicus
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95-104
2000
1
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1
1
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1
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1
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1
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1
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1
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5
-
1
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2
1
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645673
Tong
Purification and characterizat ...
Ictalurus punctatus
Arch. Biochem. Biophys.
376
409-419
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1
7
1
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1
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5
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1
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4
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9
1
1
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1
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1
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7
1
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1
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1
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4
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-
9
1
1
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-
1
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645674
Liu
Mutational analysis of the sub ...
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J. Biol. Chem.
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1
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17
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2
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1
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17
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1
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645675
Suiko
Sulfation of environmental est ...
Homo sapiens
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-
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1
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4
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14
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1
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1
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1
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1
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2
4
-
14
-
1
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-
1
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-
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-
-
-
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645676
Lin
Nucleotide binding and sulfati ...
Rattus norvegicus
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2000
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5
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1
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1
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2
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5
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5
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1
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Harris
Sulfation of 'estrogenic' alky ...
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J. Biol. Chem.
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11
1
2
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2
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14
-
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3
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-
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11
3
1
2
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2
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14
-
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645670
Dajani
Kinetic properties of human do ...
Homo sapiens
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1
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3
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1
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1
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1
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1
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1
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3
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1
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1
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1
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1
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Dajani
X-ray crystal structure of hum ...
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Effects of 3'-phosphoadenosine ...
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1
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1
2
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3
1
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645668
Dajani
A single amino acid, Glu146, g ...
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1
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3
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7
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2
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3
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15
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2
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7
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Sakakibara
Molecular cloning, expression, ...
Homo sapiens
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1
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1
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645666
Hwang
High level expression and char ...
Homo sapiens
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5
1
1
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1
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1
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1
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1
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2
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1
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4
1
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5
1
1
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1
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1
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645665
Yang
Two phenol sulfotransferase sp ...
Rattus norvegicus
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1
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1
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1
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2
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Kudlacek
Characterization of recombinan ...
Homo sapiens
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4
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2
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Sakakibara
Purification, characterization ...
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1
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645664
Ganguly
Bacterial expression and kinet ...
Homo sapiens
Drug Metab. Dispos.
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945-950
1995
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1
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Saidha
Purification and properties of ...
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Bartzatt
Inhibition of phenol sulfotran ...
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645644
Seah
2,6-Dichloro-4-nitrophenol (DC ...
Rattus norvegicus
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1994
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3
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2
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1
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3
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645655
Veronese
Functional characterization of ...
Homo sapiens
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1
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1
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1
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1
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4
1
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4
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1
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Wood
Human liver thermolabile pheno ...
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1
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1
1
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5
1
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645660
Falany
Characterization of expressed ...
Homo sapiens
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5
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5
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-
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-
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-
1
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1
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1
1
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1
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-
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5
-
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5
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-
-
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645645
Fernando
Isolation and characterization ...
Bos taurus
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30
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1993
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2
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1
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-
-
-
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-
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2
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3
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-
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-
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-
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2
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3
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-
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1
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645646
Rao
Benzylic alcohols as stereospe ...
Rattus norvegicus
Chirality
3
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1991
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2
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Falany
Purification and characterizat ...
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1
1
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2
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2
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2
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1
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1
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Pacifici
Characterization of sulphotran ...
Homo sapiens
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1989
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4
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1
1
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-
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4
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2
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-
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Weinshilboum
Phenol sulfotransferase in hum ...
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3
1
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1
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1
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-
2
1
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5
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1
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3
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1
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1
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1
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2
1
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5
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1
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645656
Whittemore
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3
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2
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1
1
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2
1
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1
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1
1
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1
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3
1
2
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1
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2
1
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1
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1
1
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645658
Whittemore
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3
2
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1
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2
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1
1
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2
2
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5
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1
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1
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3
2
2
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1
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2
2
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5
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1
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1
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645641
Romain
Partial purification and chara ...
Canis lupus familiaris
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1
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5
4
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1
1
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1
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1
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1
2
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8
-
1
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4
1
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1
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5
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4
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1
1
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1
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1
2
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8
-
1
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4
1
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645649
Rein
Multiple forms of phenolsulpho ...
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1
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4
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4
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3
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1
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644825
Sekura
Aryl sulfotransferases ...
Rattus norvegicus
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1981
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-
1
2
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3
3
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1
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1
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1
2
2
6
1
1
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9
2
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1
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2
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3
3
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1
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1
2
2
6
1
1
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9
2
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645648
Baranczyk-Kuzma
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Phenol sulfotransferases: puri ...
Rattus norvegicus
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1981
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1
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1
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1
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1
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4
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1
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2
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1
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1
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1
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4
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1
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645651
Roth
-
Characterization of human brai ...
Homo sapiens
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1981
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1
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1
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1
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1
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1
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4
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1
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1
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1
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4
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645642
Sekura
Phenol sulfotransferases ...
Rattus norvegicus
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1
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2
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1
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1
1
2
20
1
1
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14
2
1
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1
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2
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4
-
32
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2
2
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1
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1
1
2
20
1
1
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14
2
1
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645650
Pennings
Inhibition of rat brain phenol ...
Rattus norvegicus
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1976
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7
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2
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3
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7
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2
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3
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645654
Foldes
Rat brain phenolsulfotransfera ...
Rattus norvegicus
Biochim. Biophys. Acta
327
365-374
1973
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8
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1
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1
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1
1
1
9
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1
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5
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2
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8
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1
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1
1
1
9
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1
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5
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2
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