Activating Compound | Comment | Organism | Structure |
---|---|---|---|
morpholinosydnonimine | i.e. SIN-1, a peroxynitrite generator, activates SULT1A3 in vivo in Hep-G2 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | SULT1A3, kinetics and pH-dependence | Homo sapiens | |
0.0065 | - |
dopamine | SULT1A3, pH 7.0, 37°C | Homo sapiens | |
0.0316 | - |
dopamine | SULT1A3, pH 11.0, 37°C | Homo sapiens | |
0.0381 | - |
dopamine | SULT1A3, pH 9.0, 37°C | Homo sapiens | |
0.1305 | - |
3-nitro-L-tyrosine | SULT1A3, pH 7.0, 37°C | Homo sapiens | |
0.1444 | - |
3-nitro-L-tyrosine | SULT1A3, pH 5.5, 37°C | Homo sapiens | |
0.1641 | - |
3-nitro-L-tyrosine | SULT1A3, pH 9.0, 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine | Homo sapiens | sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells | adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P0DMM9 | SULT1A3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00001 | - |
SULT1A3, substrate L-DOPA | Homo sapiens |
0.00085 | - |
SULT1A3, substrate DL-3-hydroxyphenylalanine | Homo sapiens |
0.00206 | - |
SULT1A3, substrate L-tyrosine | Homo sapiens |
0.00211 | - |
SULT1A3, substrate 3-nitro-L-tyrosine | Homo sapiens |
0.01592 | - |
SULT1A3, substrate dopamine | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine | sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells | Homo sapiens | adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine | - |
? | |
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine | specific reaction of SULT1A3, not performed by other SULT isozymes | Homo sapiens | adenosine 3',5'-bisphosphate + 3-nitro-O-sulfo-L-tyrosine | - |
? | |
3'-phosphoadenylyl sulfate + DL-3-hydroxyphenylalanine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + DL-3-(sulfooxy)phenylalanine | - |
? | |
3'-phosphoadenylyl sulfate + dopamine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dopamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + L-DOPA | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + L-tyrosine | low activity | Homo sapiens | adenosine 3',5'-bisphosphate + O-sulfo-L-tyrosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SULT1A3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 10.5 | SULT1A3, broad optimum with substrate dopamine | Homo sapiens |
7 | - |
SULT1A3, with substrate 3-nitro-L-tyrosine | Homo sapiens |