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Literature summary for 2.8.2.1 extracted from

  • Sugahara, T.; Pai, T.G.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
    Differential roles of human monoamine (M)-form and simple phenol (P)-form phenol sulfotransferases in drug metabolism (2003), J. Biochem., 133, 259-262.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Co2+ P-PST, not M-PST; P-PST, slightly inhibiting with minoxidil as substrate Homo sapiens
Cu2+ M-PST and P-PST, strong inhibition Homo sapiens
Fe2+ M-PST, not P-PST Homo sapiens
Hg2+ M-PST and P-PST, strong inhibition Homo sapiens
additional information influence of divalent metal ions, overview Homo sapiens
Zn2+ P-PST and M-PST Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
dobutamine M-PST, pH 7.0, 37°C Homo sapiens
0.2
-
minoxidil P-PST, pH 7.0, 37°C Homo sapiens
0.43
-
acetaminophen M-PST, pH 7.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol M-PST Homo sapiens 5829
-
cytosol P-PST Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ P-PST, slightly stimulating with acetaminophen as substrate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + a phenol Homo sapiens phase II drug metabolizing or detoxifying enzyme adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
3'-phosphoadenylylsulfate + a phenol Homo sapiens sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds adenosine 3',5'-bisphosphate + an aryl sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activity of P-PST and M-PST with drug compounds as substrates, overview Homo sapiens
0.106
-
M-PST, substrate dobutamine Homo sapiens
0.147
-
P-PST, substrate (+/-)isoproterenol Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol
-
Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
3'-phosphoadenylylsulfate + (+/-)isoproterenol P-PST and M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + (+/-)metoprolol P-PST, not M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + (+/-)salbutamol P-PST and M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + (+/-)sotalol P-PST, not M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone P-PST and M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + a phenol phase II drug metabolizing or detoxifying enzyme Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
3'-phosphoadenylylsulfate + a phenol sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
3'-phosphoadenylylsulfate + acebutolol P-PST, not M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + acetaminophen M-PST and P-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + bupivacaine P-PST, not M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + dexamethasone P-PST, not M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + DL-propanolol P-PST, not M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + dobutamine P-PST and M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + lidocaine P-PST and M-PST Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + minoxidil M-PST Homo sapiens adenosine 3',5'-bisphosphate + minoxidil sulfate
-
?
3'-phosphoadenylylsulfate + minoxidil P-PST Homo sapiens adenosine 3',5'-bisphosphate + minoxidil sulfate
-
?
additional information substrate specificity Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens