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Literature summary for 2.8.2.1 extracted from

  • Marshall, A.D.; McPhie, P.; Jakoby, W.B.
    Redox control of aryl sulfotransferase specificity (2000), Arch. Biochem. Biophys., 382, 95-104.
    View publication on PubMed
Search for more literature for 2.8.2.1

Activating Compound

Activating Compound Comment Organism Structure
additional information aryl sulfotransferase IV, oxidation causes an increase in sulfation of 4-nitrophenol and a shift of pH-optimum at physiological pH Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information ping-pong kinetics Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol aryl sulfotransferase IV Rattus norvegicus 5829
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 aryl sulfotransferase IV
-

Oxidation Stability

Oxidation Stability Organism
aryl sulfotransferase IV is sensitive to oxidation, which causes an increase in sulfation of 4-nitrophenol, but also a shift of pH-optimum at physiological pH Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate ping-pong mechanism Rattus norvegicus
a
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate aryl sulfotransferase IV: Cys66 acts as a redox switch, but is not directly involved in the cataytic mechanism Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver aryl sulfotransferase IV Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
3'-phosphoadenylylsulfate + 2-naphthol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-nitrophenol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 r
additional information substrate specificity Rattus norvegicus ?
-
 ?
additional information the liver aryl sulfotransferase IV has a very broad substrate range Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 aryl sulfotransferase IV, oxidation causes an increase in sulfation of 4-nitrophenol and a shift of pH-optimum at physiological pH Rattus norvegicus
5.5
-
 with substrate 4-nitrophenol, aryl sulfotransferase IV Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
 aryl sulfotransferase IV is ineffective at physiological pH Rattus norvegicus